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健康与营养干预研究中的脂质组学洞察

Lipidomics Insights in Health and Nutritional Intervention Studies.

作者信息

Ibáñez Clara, Mouhid Lamia, Reglero Guillermo, Ramírez de Molina Ana

机构信息

Nutritional Genomics and Food GENYAL Platform, ‡Production and Development of Foods for Health, IMDEA Food Institute , Crta. Cantoblanco, 8, 28049, Madrid, Spain.

出版信息

J Agric Food Chem. 2017 Sep 13;65(36):7827-7842. doi: 10.1021/acs.jafc.7b02643. Epub 2017 Sep 5.

Abstract

Lipids are among the major components of food and constitute the principal structural biomolecules of human body together with proteins and carbohydrates. Lipidomics encompasses the investigation of the lipidome, defined as the entire spectrum of lipids in a biological system at a given time. Among metabolomics technologies, lipidomics has evolved due to the relevance of lipids in nutrition and their well-recognized roles in health. Mass spectrometry advances have greatly facilitated lipidomics, but owing to the complexity and diversity of the lipids, lipidome purification and analysis are still challenging. This review focuses on lipidomics strategies, applications, and achievements of studies related to nutrition and health research.

摘要

脂质是食物的主要成分之一,与蛋白质和碳水化合物一起构成人体主要的结构生物分子。脂质组学包括对脂质组的研究,脂质组被定义为生物系统在特定时间的全部脂质谱。在代谢组学技术中,由于脂质在营养方面的相关性及其在健康方面公认的作用,脂质组学得到了发展。质谱技术的进步极大地促进了脂质组学,但由于脂质的复杂性和多样性,脂质组的纯化和分析仍然具有挑战性。本综述重点关注与营养和健康研究相关的脂质组学策略、应用及研究成果。

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