移植后早期JC多瘤病毒（JCPyV）肾病中无JCPyV病毒血症：一例报告

Absence of JC polyomavirus (JCPyV) viremia in early post-transplant JCPyV nephropathy: A case report.

作者信息

Janphram Chitimaporn, Worawichawong Suchin, Disthabanchong Sinee, Sumethkul Vasant, Rotjanapan Porpon

机构信息

Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Division of Renal-Pathology, Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Transpl Infect Dis. 2017 Dec;19(6). doi: 10.1111/tid.12761. Epub 2017 Oct 24.

DOI:10.1111/tid.12761

PMID:28805990

Abstract

JC polyomavirus (JCPyV)-associated nephropathy (JCPyVAN) occurs in <3% of PVAN cases after renal transplantation. We report the first confirmed case to our knowledge of JCPyVAN diagnosed by kidney biopsy in the early 6 months post transplant in Thailand. In this case report, recovery of renal allograft function was not observed after reduction of immunosuppressive agents and administration of intravenous immunoglobulin and cidofovir. Despite persistent JCPyV viruria, no significant further decline in allograft function was documented at 15 months post transplant.

摘要

肾移植后，多瘤病毒（JCPyV）相关性肾病（JCPyVAN）在移植后病毒相关性肾病（PVAN）病例中的发生率不到3%。据我们所知，我们报告了泰国首例在移植后6个月内通过肾活检确诊的JCPyVAN病例。在本病例报告中，在减少免疫抑制剂并给予静脉注射免疫球蛋白和西多福韦后，未观察到同种异体肾移植功能恢复。尽管JCPyV病毒尿持续存在，但在移植后15个月时，同种异体肾移植功能并未出现明显进一步下降。