用于近红外和短波近红外成像的 flavylium 聚甲川荧光团。
Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging.
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13126-13129. doi: 10.1002/anie.201706974. Epub 2017 Sep 14.
Bright fluorophores in the near-infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging in vivo. In this work, we utilized a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted polymethine dyes, with emission wavelengths from 680 to 1045 nm. Photophysical characterization revealed that the 1- and 3-methine dyes display enhanced photostability and the 5- and 7-methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7-methine facilitated SWIR imaging in mice. This report presents the first polymethine dye designed and synthesized for SWIR in vivo imaging.
在电磁光谱的近红外和短波近红外（SWIR）区域中，明亮的荧光团对于体内光学成像是必不可少的。在这项工作中，我们利用 7-二甲基氨基黄酮杂环构建了一系列新型的红移聚甲川染料，其发射波长范围为 680 至 1045nm。光物理特性表明，1-和 3-甲川染料显示出增强的光稳定性，而 5-和 7-甲川染料在各自的光谱区域表现出异常的亮度。7-甲川染料的胶束配方促进了小鼠的 SWIR 成像。本报告介绍了第一个专为体内 SWIR 成像设计和合成的聚甲川染料。
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