Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland; email:
Annu Rev Cell Dev Biol. 2017 Oct 6;33:23-49. doi: 10.1146/annurev-cellbio-100616-060454. Epub 2017 Aug 16.
The centriole is a beautiful microtubule-based organelle that is critical for the proper execution of many fundamental cellular processes, including polarity, motility, and division. Centriole biogenesis, the making of this miniature architectural wonder, has emerged as an exemplary model to dissect the mechanisms governing the assembly of a eukaryotic organelle. Centriole biogenesis relies on a set of core proteins whose contributions to the assembly process have begun to be elucidated. Here, we review current knowledge regarding the mechanisms by which these core characters function in an orderly fashion to assemble the centriole. In particular, we discuss how having the correct proteins at the right place and at the right time is critical to first scaffold, then initiate, and finally execute the centriole assembly process, thus underscoring fundamental principles governing organelle biogenesis.
中心粒是一种美丽的微管细胞器，对于许多基本的细胞过程的正确执行至关重要，包括极性、运动和分裂。中心粒生物发生，即这个微型建筑奇迹的产生，已成为剖析控制真核细胞器组装的机制的典范模型。中心粒生物发生依赖于一组核心蛋白，其对组装过程的贡献已开始被阐明。在这里，我们回顾了关于这些核心蛋白如何有序地发挥作用以组装中心粒的机制的现有知识。特别是，我们讨论了将正确的蛋白质放在正确的位置和正确的时间对于首先支架、然后启动、最终执行中心粒组装过程的重要性，从而强调了指导细胞器生物发生的基本原则。
