一种用于α-亚甲基-γ-酮羧酸不对称氢化的新型二茂铁基双磷配体。
A new ferrocenyl bisphosphorus ligand for the asymmetric hydrogenation of α-methylene-γ-keto-carboxylic acids.
作者信息
Chen Caiyou, Wen Songwei, Geng Mingyu, Jin Shicheng, Zhang Zhefan, Dong Xiu-Qin, Zhang Xumu
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China.
出版信息
Chem Commun (Camb). 2017 Aug 29;53(70):9785-9788. doi: 10.1039/c7cc04401a.
Upon incorporation of a noncovalent ion pair interaction, a new chiral ferrocenyl bisphosphorus ligand t-Bu-Wudaphos was developed. t-Bu-Wudaphos can be easily synthesized with very high diastereoselectivity as a highly air stable solid. The new ligand exhibited excellent reactivities and enantioselectivities in the asymmetric hydrogenation of α-methylene-γ-keto-carboxylic acids via an ion pair noncovalent interaction (up to >99% conversion, >99% ee).
通过引入非共价离子对相互作用，开发了一种新型手性二茂铁基双磷配体叔丁基-武田磷。叔丁基-武田磷可以很容易地以高非对映选择性合成，得到一种高度稳定的固体。这种新型配体通过离子对非共价相互作用，在α-亚甲基-γ-酮羧酸的不对称氢化反应中表现出优异的反应活性和对映选择性（转化率高达>99%，对映体过量值>99%）。
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