口腔扁平苔藓中肿瘤坏死因子-α的唾液和血清水平：一项系统评价与荟萃分析研究
Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study.
作者信息
Mozaffari Hamid Reza, Ramezani Mazaher, Mahmoudiahmadabadi Mohammad, Omidpanah Neda, Sadeghi Masoud
机构信息
Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Sep;124(3):e183-e189. doi: 10.1016/j.oooo.2017.06.117. Epub 2017 Jun 23.
OBJECTIVE
Tumor necrosis factor-α (TNF-α) has a role in the progression of the oral lichen planus (OLP). The aim of this meta-analysis study was to evaluate the salivary and serum TNF-α levels in patients with OLP.
STUDY DESIGN
We searched in the databases of PubMed/Medline, Science direct, Scopus, Web of Science, and Cochrane Library for studies reported from 1983 to 2016. All studies were checked for evaluation of salivary and serum levels of TNF-α in patients with OLP compared with healthy controls.
RESULTS
Twelve studies were included in the meta-analysis. The mean difference of 7 studies reporting salivary TNF-α levels in patients with OLP versus healthy controls was 25.90 pg/mL (95% confidence interval [CI] 15.31-36.49; P < .00001) and 7 studies reporting serum TNF-α levels was 1.65 pg/mL (95% CI -0.82 to 4.11; P = .19).
CONCLUSIONS
In patients with OLP, the higher levels of TNF-α in saliva compared with serum suggest that measurement of this marker in saliva may be more useful than in serum for determining diagnostic and therapeutic aims.
目的
肿瘤坏死因子-α（TNF-α）在口腔扁平苔藓（OLP）的进展中起作用。本荟萃分析研究的目的是评估OLP患者唾液和血清中的TNF-α水平。
研究设计
我们在PubMed/Medline、Science direct、Scopus、Web of Science和Cochrane图书馆的数据库中搜索了1983年至2016年报道的研究。所有研究均进行了检查，以评估OLP患者与健康对照相比唾液和血清中TNF-α的水平。
结果
12项研究纳入了荟萃分析。7项报告OLP患者唾液TNF-α水平的研究与健康对照相比的平均差异为25.90 pg/mL（95%置信区间[CI] 15.31 - 36.49；P <.00001），7项报告血清TNF-α水平的研究平均差异为1.65 pg/mL（95% CI -0.82至4.11；P = 0.19）。
结论
在OLP患者中，唾液中TNF-α水平高于血清，这表明对于确定诊断和治疗目标，检测唾液中的该标志物可能比检测血清更有用。
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