Gübitz Raphael, Lange Tobias, Gosheger Georg, Heindel Walter, Allkemper Thomas, Stehling Christoph, Gerss Joachim, Kanthak Christian, Schulte Tobias L
Department of Radiology and Neuroradiology, Asklepios Hospital Altona, Hamburg, Germany.
Department of Orthopaedics and Tumor Orthopaedics, University Hospital Münster, Münster, Germany.
Rofo. 2018 Feb;190(2):144-151. doi: 10.1055/s-0043-115898. Epub 2017 Sep 1.
To assess the T1ρ range of lumbar intervertebral discs in healthy asymptomatic individuals at 1.5 T and to investigate the influence of age, body mass index (BMI), gender, and lumbar level on T1ρ relaxation.
In a prospective study, a total of 81 volunteers aged 20 - 80 years were included in this study and divided into three age groups (A: 20 - 39y; B: 40 - 59y; C: 60 - 80y). All of the volunteers underwent magnetic resonance imaging (MRI) at 1.5 T with acquisition of sagittal T1ρ images. The calculated T1ρ relaxation times were correlated with age, BMI, gender, and lumbar level relative to the total disc, the annulus fibrosus, and the nucleus pulposus.
Age had a significant influence on T1ρ relaxation times at all lumbar levels, with increasing age being associated with reduced relaxation times. There was also a significant difference between age groups A vs. C and B vs. C (P = 0.0008 and P = 0.0149, respectively). No significant differences in T1ρ relaxation time were observed between men and women (P > 0.05). BMI showed a significant negative correlation with T1ρ relaxation times (P < 0.0001). Analysis of the lumbar level revealed a significant decrease in relaxation times from L1/2 to L5 / S1 (P = 0.0013).
Increasing age correlated significantly with advanced lumbar disc degeneration in asymptomatic individuals, particularly in those aged 60 or older. Increasing BMI correlated significantly with increasing degeneration. The lower discs showed more degeneration than the upper ones.
· Increasing age significantly reduces the T1ρ relaxation time in the intervertebral discs (P < 0.05). · Gender does not significantly influence T1ρ relaxation times (P > 0.05). · BMI shows a significant negative correlation with T1ρ relaxation times (P < 0.01). · Significantly shorter relaxation times in lower lumbar spine vs. upper lumbar spine (P < 0.01).
· Gübitz R, Lange T, Gosheger G et al. Influence of Age, BMI, Gender and Lumbar Level on T1ρ Magnetic Resonance Imaging of Lumbar Discs in Healthy Asymptomatic Adults. Fortschr Röntgenstr 2018; 190: 144 - 151.
评估1.5T场强下健康无症状个体腰椎间盘的T1ρ范围，并研究年龄、体重指数（BMI）、性别和腰椎节段对T1ρ弛豫的影响。
在一项前瞻性研究中，本研究共纳入81名年龄在20-80岁的志愿者，并将其分为三个年龄组（A组：20-39岁；B组：40-59岁；C组：60-80岁）。所有志愿者均接受1.5T场强的磁共振成像（MRI）检查，并采集矢状位T1ρ图像。计算得到的T1ρ弛豫时间与年龄、BMI、性别以及相对于整个椎间盘、纤维环和髓核的腰椎节段相关。
年龄对所有腰椎节段的T1ρ弛豫时间均有显著影响，年龄增加与弛豫时间缩短相关。A组与C组、B组与C组之间也存在显著差异（P值分别为0.0008和0.0149）。男性和女性的T1ρ弛豫时间未观察到显著差异（P>0.05）。BMI与T1ρ弛豫时间呈显著负相关（P<0.0001）。对腰椎节段的分析显示，从L1/2至L5/S1弛豫时间显著降低（P=0.0013）。
在无症状个体中，年龄增加与腰椎间盘退变进展显著相关，尤其是60岁及以上人群。BMI增加与退变加剧显著相关。较低节段的椎间盘比上节段显示出更多退变。
·年龄增加显著降低椎间盘的T1ρ弛豫时间（P<0.05）。·性别对T1ρ弛豫时间无显著影响（P>0.05）。·BMI与T1ρ弛豫时间呈显著负相关（P<0.01）。·腰椎下段的弛豫时间明显短于腰椎上段（P<0.01）。
·Gübitz R, Lange T, Gosheger G等。年龄、BMI、性别和腰椎节段对健康无症状成年人腰椎间盘T1ρ磁共振成像的影响。Fortschr Röntgenstr 2018; 190: 144-151。
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