来自溪黄草的具有生物活性的对映-贝壳杉烷二萜类化合物。
Bioactive ent-kaurane diterpenoids from Isodon rubescens.
作者信息
Zhang Yuan-Yuan, Jiang Hua-Yi, Liu Miao, Hu Kun, Wang Wei-Guang, Du Xue, Li Xiao-Nian, Pu Jian-Xin, Sun Han-Dong
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
出版信息
Phytochemistry. 2017 Nov;143:199-207. doi: 10.1016/j.phytochem.2017.08.009. Epub 2017 Sep 1.
Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC values ranging from 0.5 to 6.5 μM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
从冬凌草的地上部分分离得到了7个新的7,20-环氧-对映-贝壳杉烷二萜类化合物，即异江鲁贝素A-G，以及17个已知化合物。通过光谱方法和单晶X射线衍射对其结构进行了表征。对所有这些化合物进行了体外抗五种人肿瘤细胞系（HL-60、SMMC-7721、A-549、MCF-7和SW480）的细胞毒性评价。4个分离物对所有细胞系均表现出显著的抑制能力，IC值范围为0.5至6.5 μM；它们还强烈抑制LPS刺激的RAW264.7细胞中NO的产生。
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