向 Hunner 病变部位注射曲安奈德治疗间质性膀胱炎/膀胱疼痛综合征。
Kenalog Injection into Hunner's Lesions as a Treatment for Interstitial Cystitis/Bladder Pain Syndrome.
作者信息
Rittenberg Lauren, Morrissey Darlene, El-Khawand Dominique, Whitmore Kristene
机构信息
Division of Female Pelvic Medicine and Reconstruction, Drexel University College of Medicine, Philadephia, Pennsylvania, USA.
出版信息
Curr Urol. 2017 Aug;10(3):154-156. doi: 10.1159/000447171. Epub 2017 Jul 30.
INTRODUCTION
This study aims to evaluate the effectiveness of kenalog injection into Hunner's lesions.
MATERIALS AND METHODS
All patients had cystoscopy and bladder hydrodistention with corticosteroid injection into Hunner's lesions over a 2.5-year period. Data include patient characteristics and pre- and post-operative validated questionnaires. Spearman Correlation and Wilcoxon -tests were used for analysis.
RESULTS
One hundred patients were reviewed retrospectively. There was a 1.1 point decrease in pain at 12 weeks post-operation (p = 0.435). Urinary frequency decreased from a mean of 11.7 to 9.1 daily episodes (p = 0.05), and nocturia from a mean of 3 to 1.6 nightly episodes (p = 0.008).
CONCLUSION
The use of a corticosteroid may be beneficial to symptom control and improvement in the quality of life of interstitial cystitis/painful bladder syndrome patients. Patients had improved frequency and nocturia 12 weeks post injection.
引言
本研究旨在评估曲安奈德注射液对Hunner溃疡的疗效。
材料与方法
在2.5年的时间里，所有患者均接受了膀胱镜检查和膀胱水扩张，并向Hunner溃疡内注射了皮质类固醇。数据包括患者特征以及术前和术后经过验证的问卷。采用Spearman相关性分析和Wilcoxon检验进行分析。
结果
对100例患者进行了回顾性研究。术后12周疼痛评分下降了1.1分（p = 0.435）。尿频从平均每天11.7次减少到9.1次（p = 0.05），夜尿从平均每晚3次减少到1.6次（p = 0.008）。
结论
使用皮质类固醇可能有助于间质性膀胱炎/膀胱疼痛综合征患者控制症状并改善生活质量。注射后12周，患者的尿频和夜尿情况有所改善。
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