Ahmad Suhana, Zamry Anes Ateqah, Tan Hern-Tze Tina, Wong Kah Keng, Lim JitKang, Mohamud Rohimah
Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kelantan, Malaysia.
School of Chemical Engineering, Universiti Sains Malaysia, Engineering Campus Seri Ampangan, 14300, Nibong Tebal, Pulau Pinang, Malaysia.
Mol Immunol. 2017 Nov;91:123-133. doi: 10.1016/j.molimm.2017.09.001. Epub 2017 Sep 9.
Gold nanoparticles (NPs) have been proposed as a highly potential tool in immunotherapies due to its advantageous properties including customizable size and shapes, surface functionality and biocompatibility. Dendritic cells (DCs), the sentinels of immune response, have been of interest to be manipulated by using gold NPs for targeted delivery of immunotherapeutic agent. Researches done especially in human DCs showed a variation of gold NPs effects on cellular uptake and internalization, DC maturation and subsequent T cells priming as well as cytotoxicity. In this review, we describe the synthesis and physiochemical properties of gold NPs as well as the importance of gold NPs in immunotherapies through their actions on human DCs.
金纳米颗粒（NPs）因其具有可定制的尺寸和形状、表面功能及生物相容性等优势特性，已被视为免疫治疗中极具潜力的工具。树突状细胞（DCs）作为免疫反应的哨兵，利用金纳米颗粒对其进行操控以实现免疫治疗剂的靶向递送备受关注。特别是针对人类DCs开展的研究表明，金纳米颗粒在细胞摄取与内化、DC成熟以及后续T细胞激活，乃至细胞毒性方面的作用存在差异。在本综述中，我们描述了金纳米颗粒的合成及其物理化学性质，以及金纳米颗粒通过对人类DCs的作用在免疫治疗中的重要性。
