Martin Dominique E, Danovitch Gabriel M
Deakin University, Geelong, Victoria, Australia.
University of California, Los Angeles, Los Angeles, California, USA.
J Med Philos. 2017 Oct 1;42(5):537-558. doi: 10.1093/jmp/jhx015.
Public surveys conducted in many countries report widespread willingness of individuals to donate a kidney while alive to a family member or close friend, yet thousands suffer and many die each year while waiting for a kidney transplant. Advocates of financial incentive programs or "regulated markets" in kidneys present the problem of the kidney shortage as one of insufficient public motivation to donate, arguing that incentives will increase the number of donors. Others believe the solutions lie-at least in part-in facilitating so-called "altruistic donation;" harnessing the willingness of relatives and friends to donate by addressing the many barriers which serve as disincentives to living donation. Strategies designed to minimize financial barriers to donation and the use of paired kidney exchange programs are increasingly enabling donation, and now, an innovative program designed to address what has been termed "chronologically incompatible donation" is being piloted at the University of California, Los Angeles, and elsewhere in the United States. In this program, a person whose kidney is not currently required for transplantation in a specific recipient may instead donate to the paired exchange program; in return, a commitment is made to the specified recipient that priority access for a living-donor transplant in a paired exchange program will be offered when or if the need arises in the future. We address here potential ethical concerns related to this form of organ "banking" from living donors, and argue that it offers significant benefits without undermining the well-established ethical principles and values currently underpinning living donation programs.
在许多国家进行的公众调查显示,很多人都表示愿意在生前将肾脏捐献给家庭成员或亲密朋友,但每年仍有成千上万人在等待肾脏移植的过程中遭受痛苦,甚至死亡。肾脏经济激励计划或“规范市场”的倡导者将肾脏短缺问题归咎于公众捐赠意愿不足,认为激励措施会增加捐赠者数量。另一些人则认为,解决方案至少部分在于促进所谓的“利他性捐赠”,通过消除阻碍活体捐赠的诸多障碍,利用亲属和朋友的捐赠意愿。旨在尽量减少捐赠经济障碍和利用肾脏配对交换计划的策略越来越有助于实现捐赠。现在,加利福尼亚大学洛杉矶分校和美国其他地方正在试点一项创新计划,以解决所谓的“时间上不匹配的捐赠”问题。在这个计划中,肾脏目前在特定受者身上不需要用于移植的人可以将肾脏捐献给配对交换计划;作为回报,会向指定受者承诺,未来一旦有需要,将在配对交换计划中为活体捐赠移植提供优先机会。我们在此讨论与这种来自活体捐赠者的器官“储备”形式相关的潜在伦理问题,并认为它在不损害目前支撑活体捐赠计划的既定伦理原则和价值观的情况下,带来了显著益处。