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在巴西一家教学医院,药剂师干预对乳腺癌和妇科癌症住院患者护理过程中所拦截的处方错误。

Prescribing errors intercepted by pharmacist intervention in care of patients hospitalised with breast and gynaecological cancer at a Brazilian teaching hospital.

作者信息

Ferracini A C, Rodrigues A T, de Barros A A, Derchain S F, Mazzola P G

机构信息

Graduate Program in Medical Sciences, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.

Pharmacy Service of Women's Hospital (CAISM), University of Campinas, Campinas, SP, Brazil.

出版信息

Eur J Cancer Care (Engl). 2018 Jan;27(1). doi: 10.1111/ecc.12767. Epub 2017 Sep 19.

Abstract

Oncologic inpatients often require multiple drug therapy. They may be at higher risk of experiencing prescribing errors, which pharmacist interventions may help to avoid. This study aimed to evaluate the types of prescribing errors, pharmaceutical interventions and differences in clinical significance, in prescriptions for hospitalised patients with breast and gynaecological cancer. A cross-sectional, prospective study was conducted at the oncology ward of a clinic specialised in breast and gynaecology cancer. A clinical pharmacist analysed prescriptions, identified errors, performed interventions and classified clinical significance. A total of 1,874 prescriptions of 248 patients were evaluated; 11.5% prescriptions were involved at least in one prescribing error, totalising 283 errors. The most common error was unsafe medication due to drug interaction (89[31.4%]). Drugs for the alimentary tract and metabolism, and nervous system were the most involved in errors with statistical association (p = .0246 and p = .0002 respectively). Of the 294 interventions, 73.5% were accepted. The clinical significance of prescribing errors and interventions were classified as significant and very significant respectively. The pharmacist interventions obtained a good acceptance rate and impact significantly, avoiding prescribing errors classified as significant.

摘要

肿瘤住院患者通常需要多种药物治疗。他们出现处方错误的风险可能更高,而药剂师的干预可能有助于避免这些错误。本研究旨在评估乳腺癌和妇科癌症住院患者处方中的处方错误类型、药学干预措施以及临床意义的差异。在一家专门治疗乳腺癌和妇科癌症的诊所的肿瘤科病房进行了一项横断面前瞻性研究。一名临床药剂师分析处方、识别错误、进行干预并对临床意义进行分类。共评估了248例患者的1874张处方;11.5%的处方至少存在一处处方错误,共计283处错误。最常见的错误是因药物相互作用导致的用药不安全(89处[31.4%])。消化道和代谢药物以及神经系统药物在错误中涉及最多,具有统计学关联(分别为p = 0.0246和p = 0.0002)。在294次干预中,73.5%被接受。处方错误和干预的临床意义分别被分类为显著和非常显著。药剂师的干预获得了较高的接受率,且影响显著,避免了被分类为显著的处方错误。

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