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退伍军人全膝关节置换术后长期阿片类药物使用的风险。

Risk for Prolonged Opioid Use Following Total Knee Arthroplasty in Veterans.

机构信息

Department of Anesthesia, University of Iowa, Carver College of Medicine, Iowa City, Iowa; Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City VA Health Care System, Iowa City, Iowa.

Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City VA Health Care System, Iowa City, Iowa; Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa.

出版信息

J Arthroplasty. 2018 Jan;33(1):119-123. doi: 10.1016/j.arth.2017.08.022. Epub 2017 Aug 24.

Abstract

BACKGROUND

Patients undergoing total knee arthroplasty (TKA) may be at risk for prolonged postsurgical opioid use due to a high prevalence of persistent postsurgical pain (20%) and high rates of presurgical opioid use.

METHODS

The current study uses a Veterans Health Administration sample of 6653 Veterans who underwent TKA in the fiscal year 2014 that did not require surgical revision during the subsequent year.

RESULTS

Sixty percent of the sample had used an opioid in the year prior to surgery, including 20% who were on long-term opioid use at the time of surgery (defined as 90+ days of continuous use) and 40% with any other opioid use in the year prior to surgery. In patients on long-term opioids at the time of surgery, 69% received opioids for at least 6 months and 57% for at least 12 months after TKA. In patients not on long-term opioids at the time of TKA, only 4% received opioids for at least 6 months and 2% for at least 12 months after TKA. Differing risk factors for prolonged opioid use 12 months after TKA were identified in these 2 cohorts (ie, those who were and were not receiving long-term opioids at TKA).

CONCLUSION

These findings suggest that the greatest risk for prolonged opioid use after TKA is preoperative opioid use.

摘要

背景

接受全膝关节置换术(TKA)的患者可能由于持续手术后疼痛(20%)和术前阿片类药物使用的高发生率而面临长期术后阿片类药物使用的风险。

方法

本研究使用了退伍军人健康管理局(VA)在 2014 财年接受 TKA 且在随后一年中无需手术修正的 6653 名退伍军人的样本。

结果

样本中有 60%的人在手术前一年使用过阿片类药物,其中 20%的人在手术时长期使用阿片类药物(定义为连续使用 90 天以上),40%的人在手术前一年有任何其他阿片类药物使用。在手术时长期使用阿片类药物的患者中,69%的患者在 TKA 后至少使用 6 个月,57%的患者在 TKA 后至少使用 12 个月。在 TKA 时未长期使用阿片类药物的患者中,只有 4%的患者在 TKA 后至少使用 6 个月,2%的患者在 TKA 后至少使用 12 个月。在这两个队列(即接受和不接受 TKA 时长期使用阿片类药物的患者)中,确定了 TKA 后 12 个月长期使用阿片类药物的不同危险因素。

结论

这些发现表明,TKA 后长期使用阿片类药物的最大风险是术前阿片类药物使用。

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