钙库操纵型钙通道在癌症转移中的作用：从细胞迁移、侵袭到转移性定植。
The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization.
机构信息
School of Life Sciences, Xiamen University, Xiamen, Fujian China.
Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey, PA 17033,
出版信息
Front Biosci (Landmark Ed). 2018 Jan 1;23(7):1241-1256. doi: 10.2741/4641.
Abstract
Store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in most cancer cells. SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 and 2) and plasma membrane channel forming unit Orais (Orai 1-3). In recent years there is increasing evidence indicating that SOCE in cancer cells is dysregulated to promote cancer cell migration, invasion and metastasis. The overexpression of STIM and Orai proteins has been reported to correlate with the metastatic progression of various cancers. The hyperactive SOCE may promote metastatic dissemination and colonization by reorganizing the actin cytoskeleton, degrading the extracellular matrix and remodeling the tumor microenvironment. Here we discuss how these recent progresses provide novel insights to our understanding of tumor metastasis.
摘要
钙库操纵性钙内流（SOCE）是大多数癌细胞中主要的钙内流机制。SOCE 是由内质网钙传感器 STIMs（STIM1 和 2）和质膜通道形成单元 Orais（Orai1-3）介导的。近年来，越来越多的证据表明，癌细胞中的 SOCE 失调可促进癌细胞迁移、侵袭和转移。已有报道称，STIM 和 Orai 蛋白的过表达与各种癌症的转移进展相关。活性过高的 SOCE 可能通过重排肌动蛋白细胞骨架、降解细胞外基质和重塑肿瘤微环境来促进转移灶的扩散和定植。在这里，我们讨论这些最新进展如何为我们理解肿瘤转移提供新的见解。
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