Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, 200031, China.
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, 02138, USA.
Front Med. 2018 Jun;12(3):301-306. doi: 10.1007/s11684-017-0549-0. Epub 2017 Sep 26.
Transoral microresection for treatment of vocal cord lesions involving the anterior commissure may result in anterior glottic webs. In this study, we retrospectively reviewed 54 patients who underwent microsurgery for bilateral lesions involving the anterior commissure and categorized them into two groups. The keel placement and control groups received endoscopic keel placement and mitomycin C, respectively. During the follow-up of at least 1 year, the laryngeal web formation rate significantly decreased in the keel placement group compared with that in the control group (18.6% versus 54.5%, P < 0.05). Furthermore, the voice handicap index-10 scores for patients without web formation decreased in both the keel placement and control groups (P < 0.0001 and P < 0.001, respectively). A pseudomembrane covering the vocal cords was detected in 16.3% (7 of 43) cases after keel removal. A total of 100% (7 of 7) of these cases and 2.8% (1 of 36) of the other cases formed laryngeal webs (P < 0.0001). Endoscopic keel placement could be an effective method for preventing anterior glottic webs after surgery for bilateral vocal cord diseases involving the anterior commissure. The pseudomembrane observed at the time of keel removal may imply a high risk of web formation.
经口微创手术治疗累及前连合的声带病变可能导致前声门粘连。本研究回顾性分析了 54 例累及前连合的双侧病变患者,将其分为两组。龙骨组和对照组分别接受内镜龙骨放置和丝裂霉素 C 治疗。在至少 1 年的随访中,龙骨组的喉粘连形成率明显低于对照组(18.6%对 54.5%,P<0.05)。此外,龙骨组和对照组中无粘连形成患者的 10 项嗓音障碍指数评分均降低(P<0.0001 和 P<0.001)。龙骨去除后,16.3%(7/43)的病例检测到覆盖声带的假膜。龙骨去除后,所有病例中有 100%(7/7)和其他病例中有 2.8%(1/36)形成喉粘连(P<0.0001)。内镜龙骨放置可能是预防累及前连合的双侧声带疾病术后前声门粘连的有效方法。龙骨去除时观察到的假膜可能意味着粘连形成的风险较高。