Sun Cheng, Ding Yangyang, Wang Shimin, Hu Wei
Department of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Department of Hematology/Hematological Lab, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Pathol Oncol Res. 2019 Jan;25(1):89-95. doi: 10.1007/s12253-017-0327-y. Epub 2017 Sep 30.
Recent studies have reported that long non-coding RNA SPRY4 intron transcript 1 (SPRY4-IT1) is abnormally expressed in malignant digestive tumors and associated with prognosis. But its clinical relevance is unclear. Here, we performed a meta-analysis aims to evaluate the prognostic value of SPRY4-IT1 in digestive system malignancies. We systematic search the PubMed, Web of Science, ScienceDirect and Wiley Online Library database to eligible studies. The pooled hazard ratios (HRs) with a 95% confidence interval (95% CI) were calculated to explored the association of lncRNA SPRY4-IT1 with prognosis. Five studies were eligible for analysis, a total of 518 patients were included. Meta-analysis indicated that overexpression of SPRY4-IT1 was associated with poor over survival (OS) (HR = 1.24, 95%CI:0.49-1.98; random-effects model). The clinicopathological parameters analysis further showed that increased expression level of SPRY4-IT1 was positively correlated with lymph node metastasis (HR = 1.45, 95% CI =0.88-2.02; fixed-effects model), TNM stage (HR = 1.24,95% CI = 0.78-1.70; fixed-effects model), and invasion depth (HR = 1.25,95% CI = 0.63-1.88; fixed-effects model). lncRNA SPRY4-IT1 may serve as a potential prognostic marker in malignant digestive tumors.
最近的研究报道，长链非编码RNA SPRY4内含子转录本1（SPRY4-IT1）在恶性消化系统肿瘤中异常表达，并与预后相关。但其临床相关性尚不清楚。在此，我们进行了一项荟萃分析，旨在评估SPRY4-IT1在消化系统恶性肿瘤中的预后价值。我们系统检索了PubMed、Web of Science、ScienceDirect和Wiley Online Library数据库以获取符合条件的研究。计算合并风险比（HR）及95%置信区间（95%CI），以探讨lncRNA SPRY4-IT1与预后的关联。五项研究符合分析条件，共纳入518例患者。荟萃分析表明，SPRY4-IT1过表达与总生存期（OS）较差相关（HR = 1.24，95%CI：0.49 - 1.98；随机效应模型）。临床病理参数分析进一步显示，SPRY4-IT1表达水平升高与淋巴结转移（HR = 1.45，95%CI = 0.88 - 2.02；固定效应模型）、TNM分期（HR = 1.24，95%CI = 0.78 - 1.70；固定效应模型）及浸润深度（HR = 1.25，95%CI = 0.63 - 1.88；固定效应模型）呈正相关。lncRNA SPRY4-IT1可能作为恶性消化系统肿瘤潜在的预后标志物。
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