FOXO1：治疗消化道恶性肿瘤的另一种途径？
FOXO1: Another avenue for treating digestive malignancy?
机构信息
Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, Shaanxi, China.
出版信息
Semin Cancer Biol. 2018 Jun;50:124-131. doi: 10.1016/j.semcancer.2017.09.009. Epub 2017 Sep 28.
Abstract
Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.
摘要
消化系统恶性肿瘤是所有肿瘤中导致死亡的主要原因，2012 年全球估计有 300 万人因此死亡。近年来，其死亡率已超过肺癌和前列腺癌。转录因子叉头框 O1（FOXO1）是叉头框家族的一个关键成员，在肿瘤起始、进展和转移过程中调节多种细胞功能。在这篇综述中，我们重点关注最近研究中发现的 FOXO1 在消化系统恶性肿瘤中的抗肿瘤作用。本文旨在为进一步研究提供指导，并暗示 FOXO1 是消化系统恶性肿瘤的一个潜在治疗靶点。
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