胃复安对大鼠体内氯丙嗪吸收及药理作用的影响。

The effect of metoclopramide on the absorption and pharmacology of chlorpromazine in the rat.

作者信息

Imamura Y, Harada S, Okano Y, Miyata T, Otagiri M

机构信息

Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.

出版信息

J Pharm Pharmacol. 1988 Feb;40(2):116-9. doi: 10.1111/j.2042-7158.1988.tb05193.x.

DOI:10.1111/j.2042-7158.1988.tb05193.x

PMID:2897442

Abstract

The mechanism of interaction between metoclopramide (MCP) and chlorpromazine (CPZ) has been examined in rats. MCP given intraperitoneally 30 min before orally administered CPZ significantly enhanced the cataleptic and hypothermic effects of CPZ, and also initially increased its plasma and brain concentrations. However, MCP had no effect on the plasma and brain concentrations of CPZ given as an intravenous bolus, indicating that MCP interacts with CPZ during its intestinal absorption. Furthermore, co-administration of MCP (i.p.) with CPZ (p.o.) markedly accelerated gastric emptying compared with CPZ alone, and MCP (i.v.) did not alter the uptake of CPZ by the intestinal membrane. Therefore, it is concluded that MCP causes an increase in the rate of CPZ absorption, by accelerating the gastric emptying.

摘要

已在大鼠中研究了胃复安（MCP）与氯丙嗪（CPZ）之间的相互作用机制。在口服CPZ前30分钟腹腔注射MCP，可显著增强CPZ的僵住和体温降低作用，并且最初还会增加其血浆和脑内浓度。然而，MCP对静脉推注给予的CPZ的血浆和脑内浓度没有影响，这表明MCP在CPZ肠道吸收过程中与之相互作用。此外，与单独给予CPZ相比，MCP（腹腔注射）与CPZ（口服）共同给药可显著加速胃排空，而MCP（静脉注射）不会改变肠膜对CPZ的摄取。因此，得出的结论是，MCP通过加速胃排空导致CPZ吸收速率增加。