聚己内酯-聚（甲基丙烯酸甲酯-甲基丙烯酸二甲氨基乙酯）的表征数据及相关测定

Data of PCL-b-P(MMA-DMAEMA) characterization and related assays.

作者信息

Franco Camila, Barcelos Antonow Michelli, Beckenkamp Aline, Buffon Andréia, Ceolin Taise, Luiza Tebaldi Marli, Pozza Silveira Gustavo, Stanisçuaski Guterres Silvia, Raffin Pohlmann Adriana

机构信息

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre 90610-000, RS, Brazil.

Programa de Pós-Graduação em Nanotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752. Porto Alegre, 90610-000, RS, Brazil.

出版信息

Data Brief. 2017 Sep 19;15:111-126. doi: 10.1016/j.dib.2017.09.010. eCollection 2017 Dec.

DOI:10.1016/j.dib.2017.09.010

PMID:28975143

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5614757/

Abstract

The data presented here are related to the research paper entitled "PCL--P(MMA--DMAEMA) new triblock copolymer for novel pH-sensitive nanocapsules intended for drug delivery to tumors" by Franco et al. [1]. Characterization data of PCL-diol, macroinitiator Br-PCL-Br, homopolymers (PMMA and PDMAEMA) and copolymers (batch 1 and batch 2) analyzed by FTIR, SEC and NMR, as well as, characterization of PCL-NS formulation by laser diffraction and DLS analysis, initial nanocapsule formulations and 1-NC and 2-NC formulations, including hydrodynamic diameter at different pH media, and DMSO cytotoxicity.

摘要

此处呈现的数据与Franco等人发表的题为《用于新型pH敏感纳米胶囊的PCL - P(MMA - DMAEMA)新型三嵌段共聚物用于肿瘤药物递送》的研究论文[1]相关。通过傅里叶变换红外光谱（FTIR）、尺寸排阻色谱（SEC）和核磁共振（NMR）分析的聚己内酯二醇（PCL - diol）、大分子引发剂Br - PCL - Br、均聚物（聚甲基丙烯酸甲酯（PMMA）和聚甲基丙烯酸二甲氨基乙酯（PDMAEMA））以及共聚物（批次1和批次2）的表征数据，以及通过激光衍射和动态光散射（DLS）分析对PCL - NS制剂、初始纳米胶囊制剂以及1 - NC和2 - NC制剂的表征，包括在不同pH介质下的流体动力学直径，还有二甲基亚砜（DMSO）的细胞毒性。