幽门螺杆菌感染患者的视神经头更易受到青光眼损害吗？
Are optic nerve heads of patients with helicobacter pylori infection more susceptible to glaucomatous damage?
机构信息
Ankara Ulucanlar Eye Training and Research Hospital, Altindag/Ankara, Turkey.
Department of Gastroenterology, Ankara Numune Training and Research Hospital, Altindag/Ankara, Turkey.
出版信息
Helicobacter. 2017 Dec;22(6). doi: 10.1111/hel.12443. Epub 2017 Oct 5.
BACKGROUND
To compare retinal nerve fiber layer thicknesses (RNFLT) of patients with or without Helicobacter pylori infection and to reveal the possible RNFLT changes after H. pylori eradication.
MATERIALS AND METHODS
Sixty-five eyes of 65 patients that tested positive for H. pylori (Group 1) and 48 eyes of 48 patients that tested negative for H. pylori (Group 2) were included. RNFLT analyses were performed with spectral-domain (SD) optical coherence tomography (OCT) in a total of five regions: the superior, inferior, nasal, and temporal quadrants and the average. Then, a comparison was made between groups. After H. pylori eradication in 38 patients, RNFLTs were compared with both pre-eradication values and Group 2.
RESULTS
The groups were similar in terms of age and gender. Temporal quadrant RNFLT was thinner in Group 1 than in Group 2 (P=.02). After H. pylori eradication, RNFLTs did not differ from pre-eradication values in Group 1 (P>.05 for all), whereas temporal quadrant RNFLT after H. pylori eradication was thinner compared to Group 2 (P=.03).
CONCLUSIONS
H. pylori may cause the localized defects on RNFL that are the early signs of glaucoma.
背景
比较有和无幽门螺杆菌感染的患者的视网膜神经纤维层厚度（RNFLT），并揭示 H. pylori 根除后可能的 RNFLT 变化。
材料和方法
纳入 65 例 H. pylori 检测阳性的患者的 65 只眼（第 1 组）和 48 例 H. pylori 检测阴性的患者的 48 只眼（第 2 组）。使用谱域（SD）光学相干断层扫描（OCT）对总共有五个区域的 RNFLT 进行分析：上、下、鼻、颞象限和平均值。然后，对两组进行比较。在 38 例患者根除 H. pylori 后，将 RNFLT 与根除前的值和第 2 组进行比较。
结果
两组在年龄和性别方面相似。第 1 组的颞象限 RNFLT 比第 2 组薄（P=.02）。根除 H. pylori 后，第 1 组的 RNFLT 与根除前的值无差异（所有 P>.05），而根除 H. pylori 后的颞象限 RNFLT 比第 2 组薄（P=.03）。
结论
H. pylori 可能导致 RNFL 的局部缺陷，这是青光眼的早期迹象。
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