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大鼠腹前壁缺损所用补片的张力分析

TENSIOMETRIC ANALYSIS OF MESHES USED IN ABDOMINAL VENTRAL WALL DEFECTS IN RATS.

作者信息

Utrabo Carlos Alberto Lima, Czeczko Nicolau Gregori, Busato Cesar Roberto, Montemór-Netto Mário Rodrigues, Lipinski Leandro, Malafaia Osvaldo

机构信息

Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná, Curitiba, PR.

Medical School, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.

出版信息

Arq Bras Cir Dig. 2017 Jul-Sep;30(3):165-168. doi: 10.1590/0102-6720201700030001.

Abstract

BACKGROUND

Among the various strategies to avoid exaggerated foreign body reaction in the treatment of hernias is the limitation of the amount of polypropylene or the use of absorbable material.

AIM

To evaluate the healing of defects in the abdominal wall of rats, comparing microporous polypropylene, macroporous polypropylene and polypropylene/polyglecaprone at the 30º, 60º and 120º postoperative day.

METHODS

Wistar rats were submitted to defect production in the ventral abdominal wall, with integrity of the parietal peritoneum. Prolene®, Ultrapro® and Bard Soft® meshes were used in the correction of the defect. Nine subgroups of 10 animals were submitted to euthanasia at 30th, 60th and 120th postoperative day. Fragments of the abdominal wall of the animals were submitted to tensiometric analysis.

RESULTS

The tensiometry at the 30th postoperative day showed greater resistance of the tissues with Bard Soft® (macroporous mesh) in relation to the tissues with Prolene® (microporous mesh). On the 60th postoperative day Bard Soft® maintained the superior resistance to the tissues comparing to Prolene Mesh®. On the 120th postoperative day the tissues repaired with Ultrapro® (macroporous mesh) proved to be more resistant than the ones by Prolene® (microporous mesh) and Bard Soft® (macroporous mesh).

CONCLUSION

The tissues repaired with macroporous meshes showed greater resistance than with microporous meshes at all stages, and at 120 days postoperative Ultrapro® performed better than the others.

摘要

背景

在疝治疗中,避免过度异物反应的各种策略包括限制聚丙烯的用量或使用可吸收材料。

目的

比较微孔聚丙烯、大孔聚丙烯和聚丙烯/聚乙交酯乙交酯在术后第30天、60天和120天对大鼠腹壁缺损的愈合情况进行评估。

方法

将Wistar大鼠的腹前壁制造缺损,保留壁层腹膜完整。使用普理灵®、优普隆®和巴德柔软®补片修复缺损。术后第30天、60天和120天,将9个亚组(每组10只动物)实施安乐死。对动物腹壁组织进行张力分析。

结果

术后第30天的张力测定显示,与使用普理灵®(微孔补片)的组织相比,使用巴德柔软®(大孔补片)的组织具有更大的抗张强度。术后第60天,与普理灵补片相比,巴德柔软®对组织仍保持较高的抗张强度。术后第120天,用优普隆®(大孔补片)修复的组织比用普理灵®(微孔补片)和巴德柔软®(大孔补片)修复的组织更具抗张强度。

结论

在各个阶段,用大孔补片修复的组织比用微孔补片修复的组织具有更大的抗张强度,且在术后120天时,优普隆®的表现优于其他补片。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ec/5630206/4ca2c2e7068f/0102-6720-abcd-30-03-00165-gf1.jpg

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