5-羟色胺受体拮抗剂在治疗阿片类药物引起的瘙痒中是否有作用？

Is There a Role for 5-HT Receptor Antagonists in the Treatment of Opioid-Induced Pruritus?

作者信息

Rashid Saima, Trivedi Disha D, Al-Shathir Mudher, Moulton Marie, Baumrucker Steven J

机构信息

1 Department of Pulmonary and Critical Care, Mercy Health, Cincinnati, OH, USA.

2 Fawcett Memorial Hospital, Port Charlotte, FL, USA.

出版信息

Am J Hosp Palliat Care. 2018 Apr;35(4):740-744. doi: 10.1177/1049909117736062. Epub 2017 Oct 11.

DOI:10.1177/1049909117736062

PMID:29020799

Abstract

Pruritus is an unpleasant irritation symptom that can be related to various systemic and dermatological conditions. Although underreported, pruritus is a common adverse event noted after use of opioid pain medications. This article reviews the current understanding of the mechanism of opioid-induced pruritus (OIP) and various pharmacological therapies. 5-Hydroxytryptamine 3 (5-HT) receptor antagonists are potentially effective for treating OIP and may be a valuable treatment option if further controlled studies are encouraging.

摘要

瘙痒是一种令人不适的刺激性症状，可能与多种全身性和皮肤病学状况相关。尽管报告不足，但瘙痒是使用阿片类镇痛药物后常见的不良事件。本文综述了目前对阿片类药物引起的瘙痒（OIP）机制的理解以及各种药物治疗方法。5-羟色胺3（5-HT）受体拮抗剂可能对治疗OIP有效，如果进一步的对照研究结果令人鼓舞，可能会成为一种有价值的治疗选择。