胰腺嗜酸性细胞型导管内乳头状黏液性肿瘤伴异常低黏液分泌，酷似导管内管状乳头状肿瘤：1例经术前内镜活检确诊的病例报告
Oncocytic Type Intraductal Papillary Mucinous Neoplasm of the Pancreas with Unusually Low Mucin Production Mimicking Intraductal Tubulopapillary Neoplasm: A Report of a Case Diagnosed by a Preoperative Endoscopic Biopsy.
作者信息
Yoshida Yukinari, Endo Takao, Tanaka Eiichi, Kikuchi Takefumi, Akino Kimishige, Mita Hiroaki, Adachi Yasuyo, Nakamura Masahiro, Adachi Yasushi, Ishii Yoshifumi, Matsumoto Joe, Hirano Satoshi, Nitta Takeo, Mitsuhashi Tomoko, Kato Yasuo
机构信息
Department of Gastroenterology, Sapporo Shirakabadai Hospital, Japan.
Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Japan.
出版信息
Intern Med. 2017 Dec 1;56(23):3183-3188. doi: 10.2169/internalmedicine.9053-17. Epub 2017 Oct 11.
We herein report the case of a 78-year-old woman with an intraductal tumor with scant mucin production in a moderately dilated main pancreatic duct that resembled an intraductal tubulopapillary neoplasm (ITPN) on imaging. An endoscopic transpapillary forceps biopsy enabled an accurate preoperative diagnosis of the tumor as an oncocytic type intraductal papillary mucinous neoplasm (IPMN) of the pancreas microscopically showing papillary growth consisting of oncocytic cells with a typical mucin expression profile, although with few intraepithelial lumina containing mucin. This is the first case of an oncocytic type IPMN mimicking an ITPN that was able to be diagnosed preoperatively.
我们在此报告一例78岁女性病例，其主胰管中度扩张，内有导管内肿瘤，黏液分泌稀少，影像学上类似导管内管状乳头状肿瘤（ITPN）。内镜经乳头钳取活检术实现了术前对肿瘤的准确诊断，显微镜下该肿瘤为胰腺嗜酸性细胞型导管内乳头状黏液性肿瘤（IPMN），表现为嗜酸性细胞构成的乳头状生长，具有典型的黏液表达谱，尽管含有黏液的上皮内管腔较少。这是首例术前得以诊断的模仿ITPN的嗜酸性细胞型IPMN。
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