溶质转运与上皮细胞体积调节。

Solute transport and epithelial cell volume regulation.

Spring K R, Siebens A W

Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.

Comp Biochem Physiol A Comp Physiol. 1988;90(4):557-60. doi: 10.1016/0300-9629(88)90667-6.

Abstract

The regulation of epithelial cell volume is an essential requirement for normal tissue function and the maintenance of cellular integrity. 2. Renal papillary epithelial cells utilize an organic to compensate for the shrinkage associated with exposure to hypertonic solutions. 3. These cells synthesize the polyol, sorbitol, to increase their intracellular solute content. 4. Sorbitol is synthesized from glucose by the enzyme aldose reductase; exposure of the cells to hypertonic media causes aldose reductase synthesis and subsequent sorbitol generation over a two or three day period. 5. The intracellular signal for the formation of aldose reductase is not yet identified.

摘要

上皮细胞体积的调节是正常组织功能和维持细胞完整性的基本要求。2. 肾乳头上皮细胞利用一种有机物来补偿因暴露于高渗溶液而导致的细胞收缩。3. 这些细胞合成多元醇山梨醇以增加其细胞内溶质含量。4. 山梨醇由醛糖还原酶从葡萄糖合成；细胞暴露于高渗介质会导致醛糖还原酶合成，并在两到三天内随后生成山梨醇。5. 醛糖还原酶形成的细胞内信号尚未确定。