Cooper Edwin L, Ma Melissa J
Laboratory of Comparative Immunology, Department of Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095-1763, USA.
J Tradit Complement Med. 2017 Jan 16;7(4):386-391. doi: 10.1016/j.jtcme.2016.12.002. eCollection 2017 Oct.
As we search for answers to modern medicine's most prevalent and challenging problems, the relationship between nutrition, immunity, and biological function of various natural compounds are preimminent. Nutritional research involving genomics provides rational capabilities for preventing disease. Scientific advances in genomic sequencing reveal opportunities for exploring diet-health relationships and potential for individual, genotype based dietary recommendations. Utilizing molecular and genetic technology to analyze impact of nutrition on genomics and metabolism reveals that nutrients may influence certain innate and/or acquired immune functions. By analyzing immune mechanisms including their cells and complex molecules, animal models have offered relevant insight that clarifies interrelations between immunity and nutrition. Plant products also provide numerous resources through bioengineering for designing novel pharmaceuticals. Having long been employed successfully in traditional and folk medicines, plant compounds exhibit anti-inflammatory, antimicrobial, and angiogenic activity. As a result, we now have a promising arsenal for successful application of bioactive compounds.
在我们探寻现代医学中最普遍且具挑战性问题的答案时,营养、免疫与各种天然化合物生物学功能之间的关系至关重要。涉及基因组学的营养研究为疾病预防提供了合理的能力。基因组测序的科学进展揭示了探索饮食与健康关系以及基于个体基因型进行饮食建议的潜力。利用分子和基因技术分析营养对基因组学和新陈代谢的影响表明,营养素可能会影响某些先天和/或后天免疫功能。通过分析包括免疫细胞和复杂分子在内的免疫机制,动物模型提供了相关见解,阐明了免疫与营养之间的相互关系。植物产品还通过生物工程为设计新型药物提供了众多资源。植物化合物长期以来成功应用于传统和民间医学,具有抗炎、抗菌和血管生成活性。因此,我们现在拥有了一个有望成功应用生物活性化合物的宝库。