英格兰和威尔士猪圆环病毒病病例中2型猪圆环病毒的特征分析
Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales.
作者信息
Grierson Sylvia S, Werling Dirk, Bidewell Cornelia, Williamson Susanna
机构信息
Department of Virology, Animal and Plant Health Agency, Woodham Lane Addlestone, Surrey, UK.
The Royal Veterinary College, Hawkshead Lane, North Mymms Hatfield, Hertfordshire, UK.
出版信息
Vet Rec. 2018 Jan 6;182(1):22. doi: 10.1136/vr.104450. Epub 2017 Oct 19.
Confirmed cases of porcine circovirus disease (PCVD) in Great Britain have shown a steady decline since the availability of porcine circovirus type 2 (PCV2) vaccines. However, PCVD is still occasionally diagnosed. The authors carried out a genotyping study to characterise PCV2 associated with confirmed PCVD cases in England and Wales from 2011 to January 2016 (n=65). A partial fragment of PCV2 genome encompassing ORF2 was amplified and sequenced from 45 cases of PCVD. The majority of sequences were genotype PCV2b but four sequences were PCV2d. The significance of the emergence of PCV2d in England and elsewhere in the world is not yet known, although it does appear to represent an ongoing global genotype shift.
自猪圆环病毒2型（PCV2）疫苗上市以来，英国确诊的猪圆环病毒病（PCVD）病例呈稳步下降趋势。然而，PCVD仍偶尔被诊断出来。作者进行了一项基因分型研究，以鉴定2011年至2016年1月在英格兰和威尔士确诊的PCVD病例中相关的PCV2（n = 65）。从45例PCVD病例中扩增并测序了包含开放阅读框2（ORF2）的PCV2基因组部分片段。大多数序列为PCV2b基因型，但有四个序列为PCV2d。PCV2d在英国及世界其他地区出现的意义尚不清楚，尽管它似乎代表着一种持续的全球基因型转变。
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