Epidemiology and Biostatistics, School of Public Health, NO. 1163 Xinmin Street, Jilin University, Changchun, Jilin, China, 130021.
Sci Rep. 2017 Oct 19;7(1):13613. doi: 10.1038/s41598-017-14045-0.
Hypertension has become a major public health challenge. However, numerous research results reported in the literature focus primarily on risk factors of hypertension, little is known about how the whole continuum of blood pressure (BP) is associated with risk factors of hypertension. This study aims to reveal quantile-specific associations of BP with its risk factors. A cross-sectional survey based on a sample of 23,050 adults aged 18 to 79 years was conducted in Jilin Province in 2012, and some subjects were excluded due to missing values in BP or having BP control according to the purpose of this study. Quantile regression (QR) was employed to investigate the associations between systolic/diastolic blood pressure (SBP/DBP) and the risk factors. The SBP and DBP in males presented statistically higher than females (P < 0.001). High-salt diet for males manifested a slightly increasing positive association with higher SBP only for high quantiles (≥70), but with a higher DBP for middle part of the quantiles (30~75), compared with bland diet. High-salt diet, drinking and high-density lipoprotein cholesterol (HDL-C) were positively associated with BP measures in males. And the coefficient of total cholesterol (TC) in QR increased with BP in females who used to live in town.
高血压已成为重大的公共卫生挑战。然而,文献中报道的大量研究结果主要集中在高血压的危险因素上,对于整个血压(BP)连续体与高血压危险因素的关系知之甚少。本研究旨在揭示 BP 与危险因素的分位数特异性关联。2012 年在吉林省进行了一项基于 23050 名 18 至 79 岁成年人样本的横断面调查,由于 BP 或根据本研究目的进行 BP 控制的缺失值,一些对象被排除在外。使用分位数回归(QR)来研究收缩压/舒张压(SBP/DBP)与危险因素之间的关联。男性的 SBP 和 DBP 明显高于女性(P<0.001)。对于男性,高盐饮食与较高的 SBP 仅在较高分位数(≥70)下呈略微增加的正相关,但与中部分位数(30~75)的较高 DBP 呈正相关,而低盐饮食则相反。高盐饮食、饮酒和高密度脂蛋白胆固醇(HDL-C)与男性的 BP 测量值呈正相关。而在曾经居住在城镇的女性中,QR 中的总胆固醇(TC)系数随 BP 的增加而增加。