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Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis.苦味和甜味味觉测试可反映慢性鼻-鼻窦炎的疾病状态。
J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):1078-1080. doi: 10.1016/j.jaip.2017.09.014. Epub 2017 Oct 18.
2
Chronic Rhinosinusitis with Nasal Polyps.伴鼻息肉的慢性鼻-鼻窦炎
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[Polypous rhinosinusitis].[息肉性鼻窦炎]
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Local increase in IgE and class switch recombination to IgE in nasal polyps in chronic rhinosinusitis.慢性鼻-鼻窦炎鼻息肉中IgE的局部增加及向IgE的类别转换重组。
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Health-related quality of life and drug treatment satisfaction were low and correlated negatively with symptoms in patients having severe refractory chronic rhinosinusitis with nasal polyps.在患有严重难治性慢性鼻-鼻窦炎伴鼻息肉的患者中，与健康相关的生活质量和药物治疗满意度较低，且与症状呈负相关。
Allergol Int. 2021 Jul;70(3):370-372. doi: 10.1016/j.alit.2020.11.010. Epub 2020 Dec 25.
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Nasal polyposis (or chronic olfactory rhinitis).鼻息肉（或慢性嗅觉鼻炎）。
Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Jun;135(3):191-196. doi: 10.1016/j.anorl.2018.03.004. Epub 2018 Apr 13.
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[Polypous rhinosinusitis in the context of the asthma triad].[哮喘三联征背景下的鼻息肉性鼻窦炎]
Vestn Otorinolaringol. 2011(1):77-80.
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[Phenotypes of chronic rhinosinusitis with nasal polyps: the progresses in precision medicine].[伴鼻息肉慢性鼻-鼻窦炎的表型：精准医学的进展]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;30(3):180-2.
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Chronic rhinosinusitis: from one disease to different phenotypes.慢性鼻-鼻窦炎：从一种疾病到不同的表型。
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Pre-treatment SNOT-22 score predicts response to Endoscopic Polypectomy in Clinic (EPIC) our experience in 30 adults.治疗前SNOT-22评分可预测临床内镜下息肉切除术（EPIC）的疗效：我们对30例成人患者的经验
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Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38.对与苦味受体基因TAS2R38相关的饮食和健康结果进行全表型组研究。
Eur J Nutr. 2025 Jun 11;64(5):218. doi: 10.1007/s00394-025-03718-6.
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Assessment of Gustatory Function in Patients of Chronic Rhinosinusitis: A Case Control Study.慢性鼻窦炎患者味觉功能评估：一项病例对照研究。
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5364-5368. doi: 10.1007/s12070-024-04978-0. Epub 2024 Aug 24.
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A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments.鼻腔微生物群与各种疾病状况及新型治疗方法综述
Indian J Otolaryngol Head Neck Surg. 2023 Apr;75(Suppl 1):755-763. doi: 10.1007/s12070-022-03205-y. Epub 2022 Dec 8.
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The Diagnostic and Prognostic Role of Biomarkers in Chronic Rhinosinusitis.生物标志物在慢性鼻-鼻窦炎中的诊断和预后作用
Diagnostics (Basel). 2023 Feb 14;13(4):715. doi: 10.3390/diagnostics13040715.
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Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis.HLA-DQA1基因rs1391371风险等位基因与慢性鼻-鼻窦炎之间的关联。
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Taste receptors in chronic rhinosinusitus, what is the evidence? A systematic review.慢性鼻-鼻窦炎中的味觉感受器：有何证据？系统评价。
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Association Between Bitter Taste Receptor Phenotype and Clinical Outcomes Among Patients With COVID-19.苦味受体表型与 COVID-19 患者临床结局的相关性。
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Treatment Protocol for COVID-19 Based on T2R Phenotype.基于 T2R 表型的 COVID-19 治疗方案。
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Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients.慢性鼻-鼻窦炎患者味觉感知强度存在差异。
Int Forum Allergy Rhinol. 2021 May;11(5):857-865. doi: 10.1002/alr.22686. Epub 2020 Aug 26.
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The microbiome of the upper respiratory tract in health and disease.上呼吸道微生物组与健康和疾病。
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本文引用的文献

1
Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes.地那铵诱导的鼻窦细菌杀灭可能在慢性鼻-鼻窦炎的转归中起作用。
Int Forum Allergy Rhinol. 2017 Jul;7(7):699-704. doi: 10.1002/alr.21949. Epub 2017 May 23.
2
Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients.非息肉样慢性鼻-鼻窦炎患者T2R38味觉表型与体外生物膜形成的相关性
Int Forum Allergy Rhinol. 2016 Aug;6(8):783-91. doi: 10.1002/alr.21803. Epub 2016 Jun 16.
3
Functional roles of the sweet taste receptor in oral and extraoral tissues.甜味受体在口腔和口腔外组织中的功能作用。
Curr Opin Clin Nutr Metab Care. 2014 Jul;17(4):379-85. doi: 10.1097/MCO.0000000000000058.
4
Bitter and sweet taste receptors regulate human upper respiratory innate immunity.苦和甜味觉受体调节人体上呼吸道先天免疫。
J Clin Invest. 2014 Mar;124(3):1393-405. doi: 10.1172/JCI72094. Epub 2014 Feb 17.
5
Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa.人鼻黏膜中的单个化学感觉细胞和苦味受体信号转导。
Int Forum Allergy Rhinol. 2013 Jun;3(6):450-7. doi: 10.1002/alr.21149. Epub 2013 Feb 12.
6
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.T2R38 味觉受体多态性是上呼吸道感染易感性的基础。
J Clin Invest. 2012 Nov;122(11):4145-59. doi: 10.1172/JCI64240. Epub 2012 Oct 8.
7
Expression of taste receptors in solitary chemosensory cells of rodent airways.味觉受体在啮齿动物气道孤束化学感觉细胞中的表达。
BMC Pulm Med. 2011 Jan 13;11:3. doi: 10.1186/1471-2466-11-3.
8
Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults.TAS2R 苦味受体基因的等位基因变异与成人对常见苦味饮料的感觉和摄食行为的变化有关。
Chem Senses. 2011 Mar;36(3):311-9. doi: 10.1093/chemse/bjq132. Epub 2010 Dec 16.
9
Familial aggregation of sinonasal polyps correlates with severity of disease.鼻窦息肉的家族聚集性与疾病严重程度相关。
Otolaryngol Head Neck Surg. 2006 Apr;134(4):601-4. doi: 10.1016/j.otohns.2005.11.042.

Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis.

作者信息

Workman Alan D, Brooks Steven G, Kohanski Michael A, Blasetti Mariel T, Cowart Beverly J, Mansfield Corrine, Kennedy David W, Palmer James N, Adappa Nithin D, Reed Danielle R, Cohen Noam A

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pa.

Monell Chemical Senses Center, Philadelphia, Pa.

出版信息

J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):1078-1080. doi: 10.1016/j.jaip.2017.09.014. Epub 2017 Oct 18.

DOI:10.1016/j.jaip.2017.09.014
PMID:29054707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5904021/
Abstract
摘要