博茨瓦纳HIV阴性健康成年人的免疫血液学参考值。

Immunohaematological reference values for HIV-negative healthy adults in Botswana.

作者信息

Mine Madisa, Moyo Sikhulile, Stevens Penny, Michael Kurt, Novitsky Vladimir, Makhaola Kgomotso, Asmelash Aida, Molefhabangwe S'khatele, Woldegabriel Elias, Mothowaeng Gaseboloke, Maruta Talkmore, Kamhukamwe Charity, Mangwendeza Phibeon M, Holmes-Pretorius Molly, Mtoni Isaac, Motswaledi Modisa, Musonda Rosemary, Ndwapi Ndwapi, Makhema Joseph, Marlink Richard, Seipone Khumo, Gaolathe Tendani, Essex Max

机构信息

National Health Laboratory, Gaborone, Botswana.

Botswana-Harvard AIDS Institute Partnership (BHP), Princess Marina Hospital, Gaborone, Botswana.

出版信息

Afr J Lab Med. 2011 Dec 15;1(1):5. doi: 10.4102/ajlm.v1i1.5. eCollection 2012.

DOI:10.4102/ajlm.v1i1.5

PMID:29062725

Abstract

BACKGROUND

Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks.

OBJECTIVES

The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana.

METHOD

A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured.

RESULTS

The mean age was 28.8 (95% Confidence Interval [CI] 27.7-29.8) years, with a median of 27 years and a range 18-66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% - 12.7%) than men (15.1 g/dL; 95% CI 14.9% - 15.3%). The women's haemoglobin reference values (9.0 g/dL - 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL - 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL - 15.8 g/dL) recently defined for East and Southern Africa.

CONCLUSION

The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally.

摘要

背景

博茨瓦纳的临床实验室完全依赖于制造商试剂盒和教科书提供的正常免疫血液学值的参考区间。

目的

本研究的目的是确定博茨瓦纳健康成年人正常免疫血液学值的均值、中位数、第2.5百分位数和第97.5百分位数参考区间。

方法

在博茨瓦纳南部共招募了261名健康参与者，其中包括126名男性（48%）和135名女性（52%），并测量了免疫和血液学实验室参数。

结果

平均年龄为28.8岁（95%置信区间[CI]27.7 - 29.8），中位数为27岁，范围为18 - 66岁。女性的平均血红蛋白水平（12.4 g/dL；95% CI 12.1% - 12.7%）显著低于男性（15.1 g/dL；95% CI 14.9% - 15.3%）。女性的血红蛋白参考值（9.0 g/dL - 15.0 g/dL）低于主要为白人的人群（12.0 g/dL - 16.0 g/dL），但与最近为东非和南部非洲定义的区域共识参考区间（9.5 g/dL - 15.8 g/dL）相当。