孕期眼压及中央角膜厚度的变化：一项系统评价与Meta分析
Changes in intraocular pressure and central corneal thickness during pregnancy: a systematic review and Meta-analysis.
作者信息
Wang Chao, Li Ai-Ling, Pang Yu, Lei Ying-Qing, Yu Ling
机构信息
Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Department of the School of Public Health of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
出版信息
Int J Ophthalmol. 2017 Oct 18;10(10):1573-1579. doi: 10.18240/ijo.2017.10.15. eCollection 2017.
AIM
To conduct a Meta-analysis for investigating the variations in intraocular pressure (IOP) and central corneal thickness (CCT) during normal pregnancy.
METHODS
We searched for clinical trials published up to November 2015 without language or region restrictions in PubMed, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, Ovid, EBSCO, Elsevier, the Chinese Biomedicine Database, WanFang, CNKI, CQVIP and Google Scholar. Studies of the ocular changes observed in pregnant women were selected. The main outcomes were assessed by changes in IOP and CCT.
RESULTS
Fifteen studies were included. In subgroup analyses, IOP was significantly decreased during the second MD=-1.53, 95%CI (-2.19, -0.87); <0.00001, and third MD=-2.91, 95%CI (-3.74, -2.08); <0.00001 trimesters of pregnancy. CCT was increased during the second MD=10.12, 95%CI (2.01, 18.22); =0.01, trimester of pregnancy; moreover, during the third trimester of pregnancy, the CCT displayed an increasing trend, but the difference was not significant MD=5.98, 95%CI (-1.11, 13.07); =0.1.
CONCLUSION
A decrease in IOP is accompanied by an increase in CCT in the second and third trimesters of a normal pregnancy in women.
目的
进行一项Meta分析，以研究正常妊娠期间眼压（IOP）和中央角膜厚度（CCT）的变化。
方法
我们检索了截至2015年11月发表的临床试验，在PubMed、EMBASE、科学网、Cochrane对照试验中央注册库、Ovid、EBSCO、爱思唯尔、中国生物医学数据库、万方、知网、维普和谷歌学术中无语言或地区限制。选择观察孕妇眼部变化的研究。主要结局通过IOP和CCT的变化进行评估。
结果
纳入15项研究。在亚组分析中，妊娠第二孕中期IOP显著降低MD=-1.53，95%CI（-2.19，-0.87）；<0.00001，第三孕中期MD=-2.91，95%CI（-3.74，-2.08）；<0.00001。妊娠第二孕中期CCT增加MD=10.12，95%CI（2.01，18.22）；=0.01，此外，在妊娠第三孕中期，CCT呈上升趋势，但差异不显著MD=5.98，95%CI（-1.11，13.07）；=0.1。
结论
正常妊娠的女性在妊娠第二和第三孕中期，IOP降低伴随着CCT增加。
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