Dermatological Sciences, Institute of Cellular Medicine, University of Newcastle, UK.
Photochem Photobiol Sci. 2018 Dec 5;17(12):1941-1945. doi: 10.1039/c7pp00228a.
The earliest contribution made by Jan van der Leun to the field of photobiology was studying the mechanism of UV-induced erythema in human skin - a subject he chose for his PhD in the 1960s. His contribution to this topic encouraged us to continue this work and over a number of years in the 1980s and 1990s, we carried out several studies on quantitative aspects of UV erythema. A major part of Jan's thesis focused on diffusion processes in UV erythema and his observations led him to conclude that erythema induced by radiation with wavelengths of around 300 nm was due to the actions of a diffusing mediator arising in the epidermis, whereas radiation at shorter wavelengths around 254 nm, caused erythema by exerting a direct effect on the dermal blood vessels. By taking his data and combining them with our own studies on the dose response of UV erythema to radiation of different wavelengths, we were able to show that, contrary to Jan's conclusions, the mediator diffusion theory he developed did indeed predict that both UVB and UVC induced erythema could be explained by the action of diffusing mediators.
简·范德伦（Jan van der Leun）对光生物学领域的最早贡献是研究人类皮肤中 UV 诱导红斑的机制——他在 20 世纪 60 年代选择这个主题作为他的博士论文研究课题。他对这一课题的贡献促使我们继续开展这项工作，在 20 世纪 80 年代和 90 年代的几年里，我们对 UV 红斑的定量方面进行了几项研究。简博士论文的一个主要部分集中在 UV 红斑的扩散过程上，他的观察结果使他得出结论，波长在 300nm 左右的辐射引起的红斑是由于在表皮中产生的扩散介质的作用所致，而波长在 254nm 左右的较短辐射则通过对真皮血管产生直接作用而引起红斑。通过采用他的数据并结合我们自己对不同波长辐射的 UV 红斑剂量反应的研究，我们能够表明，与简的结论相反，他所提出的介质扩散理论确实预测，扩散介质的作用可以解释 UVB 和 UVC 引起的红斑。
