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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rechkemmer G, von Engelhardt W

Department of Physiology, School of Veterinary Medicine, Hannover, FRG.

Comp Biochem Physiol A Comp Physiol. 1988;91(4):659-63. doi: 10.1016/0300-9629(88)90944-9.

Absorption of short-chain fatty acids (SCFA), acetate, propionate, and butyrate was studied in simultaneously perfused proximal and distal segments of the colon in anaesthetized guinea pigs. 2. Acetate absorption rates increased linearly with concentration in both segments, indicating passive transport. 3. SCFA-clearance was independent of bulk luminal pH between pH 6.2 and 8.1 in the proximal and distal colon. SCFA-clearance was slightly higher in both segments at pH values less than 6. 4. The unexpected pH-independence of SCFA-absorption is attributed to the existence of a constant pH-microclimate at the surface of the colonic epithelium. 5. Relative permeabilities to acetate:propionate:butyrate were estimated as 1:1.19 +/- 0.03:1.27 +/- 0.05 in the proximal colon and 1:2.31 +/- 0.39:3.50 +/- 0.61 in the distal colon. The significance of these findings with respect to the pH-partition hypothesis are discussed.

在麻醉的豚鼠中，对同时灌注的结肠近端和远端节段中短链脂肪酸（SCFA）、乙酸盐、丙酸盐和丁酸盐的吸收进行了研究。2. 乙酸盐的吸收速率在两个节段中均随浓度呈线性增加，表明为被动转运。3. 在近端和远端结肠中，pH值在6.2至8.1之间时，SCFA清除率与管腔总体pH值无关。在pH值小于6时，两个节段中的SCFA清除率均略高。4. SCFA吸收的意外pH独立性归因于结肠上皮表面存在恒定的pH微环境。5. 近端结肠中乙酸盐：丙酸盐：丁酸盐的相对渗透率估计为1:1.19±0.03:1.27±0.05，远端结肠中为1:2.31±0.39:3.50±0.61。讨论了这些发现相对于pH分配假说的意义。

Rechkemmer G, von Engelhardt W

Department of Physiology, School of Veterinary Medicine, Hannover, FRG.

Comp Biochem Physiol A Comp Physiol. 1988;91(4):659-63. doi: 10.1016/0300-9629(88)90944-9.

Absorption of short-chain fatty acids (SCFA), acetate, propionate, and butyrate was studied in simultaneously perfused proximal and distal segments of the colon in anaesthetized guinea pigs. 2. Acetate absorption rates increased linearly with concentration in both segments, indicating passive transport. 3. SCFA-clearance was independent of bulk luminal pH between pH 6.2 and 8.1 in the proximal and distal colon. SCFA-clearance was slightly higher in both segments at pH values less than 6. 4. The unexpected pH-independence of SCFA-absorption is attributed to the existence of a constant pH-microclimate at the surface of the colonic epithelium. 5. Relative permeabilities to acetate:propionate:butyrate were estimated as 1:1.19 +/- 0.03:1.27 +/- 0.05 in the proximal colon and 1:2.31 +/- 0.39:3.50 +/- 0.61 in the distal colon. The significance of these findings with respect to the pH-partition hypothesis are discussed.

在麻醉的豚鼠中，对同时灌注的结肠近端和远端节段中短链脂肪酸（SCFA）、乙酸盐、丙酸盐和丁酸盐的吸收进行了研究。2. 乙酸盐的吸收速率在两个节段中均随浓度呈线性增加，表明为被动转运。3. 在近端和远端结肠中，pH值在6.2至8.1之间时，SCFA清除率与管腔总体pH值无关。在pH值小于6时，两个节段中的SCFA清除率均略高。4. SCFA吸收的意外pH独立性归因于结肠上皮表面存在恒定的pH微环境。5. 近端结肠中乙酸盐：丙酸盐：丁酸盐的相对渗透率估计为1:1.19±0.03:1.27±0.05，远端结肠中为1:2.31±0.39:3.50±0.61。讨论了这些发现相对于pH分配假说的意义。