减重手术中的维生素 D 代谢。

Vitamin D Metabolism in Bariatric Surgery.

机构信息

Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Riad El Solh, Beirut, Lebanon.

出版信息

Endocrinol Metab Clin North Am. 2017 Dec;46(4):947-982. doi: 10.1016/j.ecl.2017.07.006.

DOI:10.1016/j.ecl.2017.07.006

PMID:29080645

Abstract

Hypovitaminosis D is common in obese patients and persists after roux-en-Y gastric bypass and sleeve gastrectomy. Several societies recommend screening for vitamin D deficiency before bariatric surgery, and replacement doses of 3000 IU/d and up to 50,000 IU 1 to 3 times per week, in case of deficiency, with periodic monitoring. These regimens are mostly based on expert opinion. Large trials are needed to assess the vitamin D dose response, by type of bariatric surgery, and evaluate the effect on surrogate markers of skeletal outcomes. Such data are essential to derive desirable vitamin D levels in this population.

摘要

肥胖患者常发生维生素 D 缺乏，且在 Roux-en-Y 胃旁路术和袖状胃切除术之后仍持续存在。一些学会建议在进行减重手术之前筛查维生素 D 缺乏症，如果存在缺乏，应补充 3000IU/d 的剂量，并且每周 1 至 3 次补充至 50,000IU，同时定期监测。这些方案主要基于专家意见。需要开展大型试验来评估不同减重手术类型的维生素 D 剂量反应，并评估对骨骼结局替代标志物的影响。此类数据对于确定该人群的理想维生素 D 水平至关重要。