Rab蛋白是高尔基体复合体结构的主要决定因素。
Rab proteins as major determinants of the Golgi complex structure.
作者信息
Goud Bruno, Liu Shijie, Storrie Brian
机构信息
a Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport , Paris , France.
b Department of Physiology and Biophysics , University of Arkansas for Medical Sciences , Little Rock , USA.
出版信息
Small GTPases. 2018 Mar 4;9(1-2):66-75. doi: 10.1080/21541248.2017.1384087. Epub 2018 Jan 29.
Abstract
GTP-ases of the Rab family (about 70 in human) are key regulators of intracellular transport and membrane trafficking in eukaryotic cells. Remarkably, almost one third associate with membranes of the Golgi complex and TGN (trans-Golgi network). Through interactions with a variety of effectors that include molecular motors, tethering complexes, scaffolding proteins and lipid kinases, they play an important role in maintaining Golgi architecture.
摘要
Rab家族的GTP酶（人类中约有70种）是真核细胞内细胞运输和膜运输的关键调节因子。值得注意的是，几乎三分之一的Rab家族GTP酶与高尔基体复合体和反式高尔基体网络（TGN）的膜相关联。通过与包括分子马达、拴系复合体、支架蛋白和脂质激酶在内的多种效应器相互作用，它们在维持高尔基体结构中发挥重要作用。
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