Kochkin D V, Globa E B, Demidova E V, Gaisinsky V V, Galishev B A, Kolotyrkina N G, Kuznetsov Vl V, Nosov A M
Faculty of Biology, Moscow State University, Moscow, 119234, Russia.
Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, 127276, Russia.
Dokl Biochem Biophys. 2017 Sep;476(1):337-339. doi: 10.1134/S1607672917050131. Epub 2017 Nov 4.
This is the first study to show that the formation of 14β-hydroxylated derivatives of taxa-4(20),11-diene is a specific feature of in vitro cultured dedifferentiated yew cells that distinguishes them from intact plant cells. This may be due to a lower toxicity of the 14-OH taxoids for proliferating plant cells compared to the 13-OH derivatives.
这是第一项表明紫杉-4(20),11-二烯的14β-羟基化衍生物的形成是体外培养的去分化红豆杉细胞的一个特定特征，这使其与完整植物细胞区分开来的研究。这可能是由于与13-羟基衍生物相比，14-羟基紫杉烷类对增殖植物细胞的毒性较低。
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