Yawn Barbara P, Han MeiLan K
Department of Family Medicine and Community Health, University of Minnesota, Blaine, MN.
Women's Respiratory Clinic, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI.
Mayo Clin Proc. 2017 Nov;92(11):1697-1705. doi: 10.1016/j.mayocp.2017.08.005. Epub 2017 Nov 1.
Although often considered a disease of childhood, the prevalence of asthma in US adults aged 65 years or older is similar to that in children, with the number of older patients needing care for asthma likely to continue to increase. As with most chronic diseases, there are challenges associated with the diagnosis and management of asthma in an older population. This review discusses these challenges, suggesting practical management strategies for primary care physicians and their teams. Asthma comprises a spectrum of phenotypes, some associated with adult onset. The symptoms and characteristics of patients with late-onset asthma can differ from those of patients with early-onset disease. Furthermore, older patients may fail to recognize respiratory symptoms as abnormal and have other comorbidities, complicating the differential diagnosis of asthma. Once diagnosed, the long-term goals of asthma management are no different in older adults than in anyone with asthma, with inhaled corticosteroids being the cornerstone of therapy. Comorbid conditions become more common with age and have a direct impact on a patient's respiratory symptoms and potential adverse effects of therapy, thereby influencing the choice of therapies and delivery systems and potentially increasing the likelihood of complex polypharmacy. In conclusion, asthma, although traditionally considered a disease of the young, should be considered as a potential diagnosis in older adults with respiratory symptoms, even without a history of asthma or allergies. As with all patients, the primary goals of asthma management in older adults are symptom control and exacerbation reduction.
尽管哮喘通常被认为是一种儿童疾病,但在美国65岁及以上的成年人中,哮喘的患病率与儿童相似,且需要哮喘护理的老年患者数量可能会持续增加。与大多数慢性疾病一样,老年人群中哮喘的诊断和管理存在挑战。本综述讨论了这些挑战,并为初级保健医生及其团队提出了切实可行的管理策略。哮喘包括一系列表型,其中一些与成人发病有关。迟发性哮喘患者的症状和特征可能与早发性疾病患者不同。此外,老年患者可能无法认识到呼吸道症状异常,且患有其他合并症,这使得哮喘的鉴别诊断变得复杂。一旦确诊,哮喘管理的长期目标在老年人中与任何哮喘患者并无不同——吸入性糖皮质激素是治疗的基石。合并症随着年龄增长变得更为常见,并且对患者的呼吸道症状以及治疗的潜在不良反应有直接影响,从而影响治疗方法和给药系统的选择,并可能增加复杂多药联用的可能性。总之,哮喘尽管传统上被认为是一种年轻人的疾病,但对于有呼吸道症状的老年人,即使没有哮喘或过敏史,也应将其视为一种潜在的诊断。与所有患者一样,老年哮喘患者管理的主要目标是控制症状和减少发作。