School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.
Biomed Res Int. 2017;2017:3684971. doi: 10.1155/2017/3684971. Epub 2017 Aug 13.
To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age.
Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT).
The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age.
CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.
研究兔眼角膜临床生物力学参数（CCBP）和角膜几何参数随年龄的变化。
纳入 3、7、12、18 和 24 月龄的兔子。使用眼反应分析仪（ORA）、光学相干断层扫描（OCT）和角膜测厚仪对每只兔子的眼睛进行测试，以获得眼内压（IOP）：Goldmann 相关眼压（IOPg）和角膜补偿眼压（IOPcc）；CCBP：角膜滞后（CH）和角膜阻力因子（CRF）；角膜几何参数：角膜曲率半径（CCR）和中央角膜厚度（CCT）。
兔子的 IOP 从 3 个月到 7 个月龄略有下降，从 7 个月龄到 18 个月龄显著下降，从 18 个月龄到 24 个月龄上升；CH 和 CRF 随年龄增加而降低；CCT 从 7 个月龄增加到 18 个月龄，从 3 个月龄减少到 7 个月龄，从 18 个月龄减少到 24 个月龄；CCR 从 3 个月龄到 18 个月龄呈上升趋势，从 18 个月龄到 24 个月龄显著下降。
CH 和 CRF 与年龄呈负相关。CCT 和 CCR 与年龄呈正相关。
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