血清γ-谷氨酰转移酶和 C 反应蛋白与视神经脊髓炎和多发性硬化的相关性。
Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis.
机构信息
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Perth, Australia; Institute of Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
出版信息
Mult Scler Relat Disord. 2017 Nov;18:65-70. doi: 10.1016/j.msard.2017.09.021. Epub 2017 Sep 20.
BACKGROUND
Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown.
METHODS
We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC). Clinical parameters, blood-brain barrier (BBB) index and Delpech index of MS and NMO were also investigated.
RESULTS
We found that NMO patients had higher serum GGT and CRP levels within their normal ranges compared to MS, PD, healthy controls. NMO patients exhibited significantly higher EDSS scores than MS patients. The BBB index in NMO patients was significantly higher than that in MS patients. Significant correlations existed between serum GGT and CRP levels and EDSS scores, BBB index in NMO and MS patients.
CONCLUSION
Elevated GGT and CRP levels within their normal ranges in NMO and MS may be associated with inflammatory response, oxidative stress and BBB disturbance in the diseases. Further study into the underlying pathophysiology of this relationship is warranted.
背景
许多研究表明，血清γ-谷氨酰转移酶（GGT）在正常范围内可能是氧化应激的早期标志物。然而，GGT 在视神经脊髓炎（NMO）和多发性硬化（MS）中的作用尚不清楚。
方法
我们评估了 GGT 与 C 反应蛋白（CRP）水平之间的相关性，以及 NMO 和 MS 的临床特征。我们测量了 106 例 NMO 患者、87 例 MS 患者、79 例非炎症性神经疾病（帕金森病）患者和 80 例健康对照者（HC）的血清 GGT 和 CRP 水平。还研究了 MS 和 NMO 的临床参数、血脑屏障（BBB）指数和 Delpech 指数。
结果
我们发现，与 MS、PD、健康对照者相比，NMO 患者的血清 GGT 和 CRP 水平在正常范围内更高。NMO 患者的 EDSS 评分明显高于 MS 患者。NMO 患者的 BBB 指数明显高于 MS 患者。NMO 和 MS 患者的血清 GGT 和 CRP 水平与 EDSS 评分、BBB 指数之间存在显著相关性。
结论
NMO 和 MS 患者血清 GGT 和 CRP 水平在正常范围内升高可能与疾病中的炎症反应、氧化应激和 BBB 紊乱有关。需要进一步研究这种关系的潜在病理生理学。
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