阿尔茨海默病患者淋巴细胞的放射敏感性。
Radiosensitivity of lymphocytes from patients with Alzheimer's disease.
作者信息
Smith T A, Itzhaki R F
机构信息
Department of Ophthalmic Optics, University of Manchester Institute of Science and Technology, Great Britain.
出版信息
Mutat Res. 1989 Jan;217(1):11-7. doi: 10.1016/0921-8777(89)90030-x.
The response after gamma-irradiation of lymphocytes from 8 patients with Alzheimer's disease (AD), 3 patients with Huntington's disease and 13 normal subjects to stimulation by phytohaemagglutinin (PHA) was assayed by incorporation of [3H]thymidine. The response of non-irradiated cells was found to be significantly lower in AD cells than in age-matched normals but not significantly lower in old normals than in young normals. However, the response of irradiated cells to PHA, expressed as a percentage of that in non-irradiated cells, was found to be similar in AD patients, young and old normals and in HD patients.
通过[3H]胸苷掺入法，检测了8例阿尔茨海默病（AD）患者、3例亨廷顿病患者及13名正常受试者的淋巴细胞经γ射线照射后对植物血凝素（PHA）刺激的反应。结果发现，未照射细胞的反应在AD患者细胞中显著低于年龄匹配的正常细胞，但老年正常细胞的反应并不显著低于年轻正常细胞。然而，照射后细胞对PHA的反应，以未照射细胞反应的百分比表示，在AD患者、年轻和老年正常受试者以及HD患者中相似。
Zotero 插件