Regioselective synthesis of 2,3'-biindoles mediated by an NBS-induced homo-coupling of indoles.
作者信息
Huang Panpan, Peng Xiangjun, Hu Dan, Liao Huiwu, Tang Shaobin, Liu Liangxian
机构信息
Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. China.
出版信息
Org Biomol Chem. 2017 Nov 22;15(45):9622-9629. doi: 10.1039/c7ob02312j.
PMID:29114681
Abstract
Mild conditions have been developed to achieve NBS-induced homodimerization of indole derivatives with excellent regioselectivity at 15 °C in high efficiency. This method provides a simple route to a 2,3'-linked biindolyl scaffold from the electron-rich to moderately electron-poor indoles. In addition, [3,2-a]carbazole derivatives can also be prepared through this method.
摘要
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