Tang Jin-Ying, Liu Yan-Ping, Ju Peng-Kun, Luo Xiu-Lan, Zhang Zhi-Jie, Ren Peng, Lai Liang, Chen Guang-Ying, Fu Yan-Hui
a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.
b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
Nat Prod Res. 2018 Jul;32(14):1727-1732. doi: 10.1080/14786419.2017.1399388. Epub 2017 Nov 8.
A new polyoxygenated cyclohexene derivative, artahainanol A (1), together with three known analogues (2-4), was isolated from the stems and leaves of Artabotrys hainanensis. Among them, 1 is an unusual polyoxygenated cyclohexene containing 14 carbon atoms on the carbon skeleton. All known compounds (2-4) were isolated from the genus Artabotrys for the first time. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-4 showed significant inhibitory effects against various human cancer cell lines with IC values ranging from 2.68 to 18.32 μM.
从海南鹰爪花的茎和叶中分离得到一种新的多氧化环己烯衍生物海南鹰爪醇A（1），以及三个已知类似物（2 - 4）。其中，1是一种不寻常的多氧化环己烯，其碳骨架上含有14个碳原子。所有已知化合物（2 - 4）均首次从鹰爪花属植物中分离得到。通过广泛的光谱方法阐明了1的结构，并通过与文献报道的数据进行比较鉴定了已知化合物。对所有分离得到的化合物进行了体外对五种人类癌细胞系（HL - 60、SMMC - 7721、A - 549、MCF - 7和SW480）的细胞毒性评估。化合物1 - 4对各种人类癌细胞系显示出显著的抑制作用，IC值范围为2.68至18.32 μM。
