Wu Yuan-Seng, Ngai Siew-Ching, Goh Bey-Hing, Chan Kok-Gan, Lee Learn-Han, Chuah Lay-Hong
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.
Faculty of Science, School of Biosciences, The University of Nottingham Malaysia Campus, Semenyih, Malaysia.
Front Pharmacol. 2017 Oct 26;8:761. doi: 10.3389/fphar.2017.00761. eCollection 2017.
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis, and metastasis arrest. Owing to the potent effect of surfactin on cancer cells, numerous studies have recently investigated the mechanisms that underlie its anticancer activity. The amphiphilic nature of surfactin allows its easy incorporation nano-formulations, such as polymeric nanoparticles, micelles, microemulsions, liposomes, to name a few. The use of nano-formulations offers the advantage of optimizing surfactin delivery for an improved anticancer therapy. This review focuses on the current knowledge of surfactin properties and biosynthesis; anticancer activity against different cancer models and the underlying mechanisms involved; as well as the potential application of nano-formulations for optimal surfactin delivery.
表面活性素是一种由多种芽孢杆菌属菌株产生的环状脂肽生物表面活性剂，已被证明对多种癌症类型具有细胞毒性，如艾氏腹水癌、乳腺癌、结肠癌、白血病和肝癌。表面活性素治疗可通过生长抑制、细胞周期阻滞、凋亡和转移阻滞来抑制癌症进展。由于表面活性素对癌细胞有强大作用，最近大量研究调查了其抗癌活性的潜在机制。表面活性素的两亲性质使其易于掺入纳米制剂，如聚合物纳米颗粒、胶束、微乳液、脂质体等等。使用纳米制剂具有优化表面活性素递送以改善抗癌治疗的优势。本综述重点关注表面活性素的性质和生物合成的现有知识；对不同癌症模型的抗癌活性及其潜在机制；以及纳米制剂在优化表面活性素递送方面的潜在应用。
