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肺动脉高压研究进展:专家会议纪要

Update on pulmonary arterial hypertension research: proceedings from a meeting of experts.

作者信息

McLaughlin Vallerie, Bacchetta Matthew, Badesch David, Benza Raymond, Burger Charles, Chin Kelly, Frantz Robert, Frost Adaani, Hemnes Anna, Kim Nick H, Rosenzweig Erika B, Rubin Lewis

机构信息

a Division of Cardiovascular Medicine, Department of Internal Medicine , University of Michigan , Ann Arbor , MI , USA.

b Department of Surgery , New York Presbyterian Hospital-Columbia University Medical Center , New York , NY , USA.

出版信息

Curr Med Res Opin. 2018 Feb;34(2):263-273. doi: 10.1080/03007995.2017.1404974. Epub 2017 Dec 22.

Abstract

BACKGROUND

While pulmonary arterial hypertension (PAH) remains a progressive, symptomatic condition characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure, great strides have been made in its understanding and treatment over the past two decades.

REVIEW

Continued research in pre-clinical, clinical, and health economic areas of research, in addition to registry analyses and technology advances, is critical for understanding the pathophysiology of the disease and devising the best ways to monitor and manage patients. On December 3, 2016, the latest pre-clinical, clinical, health economic outcome, and registry data on PAH was presented in a symposium sponsored by Actelion. This paper reviews the published research and insight into upcoming research that was presented at this interactive meeting.

摘要

背景

虽然肺动脉高压(PAH)仍然是一种进行性、有症状的疾病,其特征是肺血管阻力增加,最终导致右心衰竭,但在过去二十年中,在对其的认识和治疗方面已经取得了巨大进展。

综述

除了注册分析和技术进步外,在临床前、临床和卫生经济研究领域持续开展研究,对于理解该疾病的病理生理学以及设计监测和管理患者的最佳方法至关重要。2016年12月3日,关于PAH的最新临床前、临床、卫生经济结果和注册数据在Actelion主办的一次研讨会上公布。本文回顾了在这次互动会议上发表的研究以及对即将开展的研究的见解。

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