[血浆爱泼斯坦-巴尔病毒DNA在弥漫性大B细胞淋巴瘤患者中的预后意义]

[The prognostic significance of plasma Epstein-Barr virus DNA in patients with diffuse large B cell lymphoma].

作者信息

An N, Xie Y P, Xu Y, Shi P F, Qian S X

机构信息

Department of Hematology, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou 310006, China.

出版信息

Zhonghua Nei Ke Za Zhi. 2017 Nov 1;56(11):839-841. doi: 10.3760/cma.j.issn.0578-1426.2017.11.012.

DOI:10.3760/cma.j.issn.0578-1426.2017.11.012

PMID:29136714

Abstract

To retrospectively analyze the prognostic significance of plasma Epstein-Barr virus (EBV) DNA in 122 patients with diffuse large B cell lymphoma (DLBCL). Plasma EBV DNA positivity was related to advanced disease stage (=0.030), B symptoms (=0.004) and elevated serum lactic dehydrogenase (LDH) (=0.001). Furthermore, univariate analysis indicated that plasma EBV DNA level was associated with worse overall survival (OS) (=0.223, 95% 0.096-0.518, <0.001) and worse progression free survival (PFS) (=4.417, 95% 1.911-10.208, <0.001), whereas multivariate analysis showed plasma EBV DNA as a probable independent prognostic factor of clinical outcome(=0.409, 95% 0.166-1.008, =0.052).

摘要

回顾性分析122例弥漫性大B细胞淋巴瘤（DLBCL）患者血浆中EB病毒（EBV）DNA的预后意义。血浆EBV DNA阳性与疾病晚期（P=0.030）、B症状（P=0.004）及血清乳酸脱氢酶（LDH）升高（P=0.001）相关。此外，单因素分析表明血浆EBV DNA水平与较差的总生存期（OS）（P=0.223，95%可信区间0.096-0.518，P<0.001）及较差的无进展生存期（PFS）（P=4.417，95%可信区间1.911-10.208，P<0.001）相关，而多因素分析显示血浆EBV DNA可能是临床结局的独立预后因素（P=0.409，95%可信区间0.166-1.008，P=0.052）。