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[1995 - 2015年北京地区艾滋病病毒/艾滋病病例生存时间及相关因素]

[Survival time of HIV/AIDS cases and related factors in Beijing, 1995-2015].

作者信息

Li Y, Wang J, He S F, Chen J, Lu H Y

机构信息

Department of AIDS/STD Control and Prevention, Beijing Municipal Center for Disease Control and Prevention, Beijing Center for Preventive Medical Research, Beijing 100013, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Nov 10;38(11):1509-1513. doi: 10.3760/cma.j.issn.0254-6450.2017.11.014.

Abstract

To analyze the survival time of HIV/AIDS cases and related factors in Beijing from 1995 to 2015. A retrospective cohort study was conducted to analyze the data of 12 874 HIV/AIDS cases. The data were collected from Chinese HIV/AIDS Comprehensive Information Management System. Life table method was applied to calculate the survival proportion, and Cox proportion hazard regression model were used to identify the factors related with survival time. Among 12 874 HIV/AIDS cases, 303 (2.4%) died of AIDS related diseases; 9 346 (72.6%) received antiretroviral therapy. The average survival time was 226.5 months (95: 223.0-230.1), and the survival rates of 1, 5, 10, and 15 years were 98.2%, 96.4%, 93.2%, and 91.9% respectively. Multivariate Cox proportion hazard regression model showed that AIDS phase (=1.439, 95: 1.041-1.989), heterosexual transmission (=1.646, 95: 1.184-2.289), being married (=2.186, 95: 1.510-3.164); older age (≥60 years) at diagnosis (=6.608, 95: 3.546-12.316); lower CD(4)(+)T cell counts at diagnosis (<350 cells/μl) (=8.711, 95: 5.757-13.181); receiving no antiretroviral therapy (ART) (=18.223, 95: 13.317-24.937) were the high risk factors influencing the survival of AIDS patients compared with HIV phase, homosexual transmission, being unmarried, younger age (≤30 years), higher CD(4)(+)T cell count (≥350 cell/μl) and receiving ART. The average survival time of HIV/AIDS cases was 226.5 months after diagnoses. Receiving ART, higher CD(4)(+)T cell counts at the first test, HIV phase, younger age, being unmarried and the homosexual transmission were related to the longer survival time of HIV/AIDS cases. Receiving no ART, the lower CD(4)(+)T cell counts at the first test, AIDS phase, older age, being married and heterosexual transmission indicated higher risk of death due to AIDS.

摘要

分析1995年至2015年北京市艾滋病病毒/艾滋病(HIV/AIDS)病例的生存时间及相关因素。开展一项回顾性队列研究,分析12874例HIV/AIDS病例的数据。数据来源于中国HIV/AIDS综合信息管理系统。采用寿命表法计算生存比例,并用Cox比例风险回归模型识别与生存时间相关的因素。在12874例HIV/AIDS病例中,303例(2.4%)死于艾滋病相关疾病;9346例(72.6%)接受了抗逆转录病毒治疗。平均生存时间为226.5个月(95%可信区间:223.0 - 230.1),1年、5年、10年和15年的生存率分别为98.2%、96.4%、93.2%和91.9%。多因素Cox比例风险回归模型显示,与HIV感染阶段、同性传播、未婚、年龄较小(≤30岁)、CD4(+)T细胞计数较高(≥350个/μl)和接受抗逆转录病毒治疗相比,艾滋病期(风险比=1.439,95%可信区间:1.041 - 1.989)、异性传播(风险比=1.646,95%可信区间:1.184 - 2.289)、已婚(风险比=2.186,95%可信区间:1.510 - 3.164)、诊断时年龄较大(≥60岁)(风险比=6.608,95%可信区间:3.546 - 12.316)、诊断时CD4(+)T细胞计数较低(<350个/μl)(风险比=8.711,95%可信区间:5.757 - 13.181)、未接受抗逆转录病毒治疗(ART)(风险比=18.223,95%可信区间:13.317 - 24.937)是影响艾滋病患者生存的高危因素。HIV/AIDS病例诊断后的平均生存时间为226.5个月。接受ART、首次检测时CD4(+)T细胞计数较高、HIV感染阶段、年龄较小、未婚和同性传播与HIV/AIDS病例较长的生存时间相关。未接受ART、首次检测时CD4(+)T细胞计数较低、艾滋病期、年龄较大、已婚和异性传播提示因艾滋病死亡的风险较高。

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