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癌症治疗的心血管并发症:诊断、预防及管理的最佳实践:第1部分

Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1.

作者信息

Chang Hui-Ming, Moudgil Rohit, Scarabelli Tiziano, Okwuosa Tochukwu M, Yeh Edward T H

机构信息

Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, Missouri.

Department of Cardiology, University of Texas, MD Anderson Cancer Center, Houston, Texas.

出版信息

J Am Coll Cardiol. 2017 Nov 14;70(20):2536-2551. doi: 10.1016/j.jacc.2017.09.1096.

Abstract

Modern cancer therapy has successfully cured many cancers and converted a terminal illness into a chronic disease. Because cancer patients often have coexisting heart diseases, expert advice from cardiologists will improve clinical outcome. In addition, cancer therapy can also cause myocardial damage, induce endothelial dysfunction, and alter cardiac conduction. Thus, it is important for practicing cardiologists to be knowledgeable about the diagnosis, prevention, and management of the cardiovascular complications of cancer therapy. In this first part of a 2-part review, we will review cancer therapy-induced cardiomyopathy and ischemia. This review is based on a MEDLINE search of published data, published clinical guidelines, and best practices in major cancer centers. With the number of cancer survivors expanding quickly, the time has come for cardiologists to work closely with cancer specialists to prevent and treat cancer therapy-induced cardiovascular complications.

摘要

现代癌症治疗已成功治愈了许多癌症,并将绝症转变为慢性病。由于癌症患者常常合并有心脏病,心脏病专家的专业建议将改善临床治疗结果。此外,癌症治疗还可能导致心肌损伤、诱发内皮功能障碍并改变心脏传导。因此,执业心脏病专家了解癌症治疗相关心血管并发症的诊断、预防和管理非常重要。在这个分两部分的综述的第一部分中,我们将回顾癌症治疗引起的心肌病和缺血。本综述基于对已发表数据、已发布的临床指南以及主要癌症中心的最佳实践进行的MEDLINE检索。随着癌症幸存者数量的迅速增加,心脏病专家与癌症专家密切合作以预防和治疗癌症治疗引起的心血管并发症的时候已经到来。

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