University of Southern California, Department of Obstetrics and Gynecology, Los Angeles, California.
University of Hawaii, Department of Obstetrics, Gynecology & Women's Health, Honolulu, Hawaii.
Womens Health Issues. 2018 Jan-Feb;28(1):51-58. doi: 10.1016/j.whi.2017.09.010. Epub 2017 Nov 13.
Conflicting research findings on the association of obesity and pregnancy intention may be due to their collective definition of obesity at a body mass index of 30 kg/m or greater. However, obese women with a BMI of 40 kg/m or greater may be both behaviorally and clinically different from obese women with a lower BMI. This study reexamines this relationship, stratifying by class of obesity; the study also explores variations in contraceptive use by class of obesity given their potential contribution to the incidence of unintended or unwanted pregnancy.
This study combined data from the 2006 through 2010 and 2011 through 2013 US National Survey of Family Growth. Pregnancy intention (intended, mistimed, unwanted) and current contraceptive use (no method, barrier, pill/patch/ring/injection, long-acting reversible contraceptive, sterilization) were compared across body mass index categories: normal (18.5-24.9 kg/m kg/m), overweight (25.0-29.9), obese class 1 (30.0-34.9 kg/m), class 2 (35.0-39.9 kg/m), and class 3 (≥40 kg/m, severe obesity). Weighted multinomial logistic regressions were refined to determine independent associations of body mass index class and pregnancy intention, as well as contraceptive method, controlling for demographic, socioeconomic, and reproductive factors.
Body mass index data were available for 9,848 nonpregnant, sexually active women who reported not wanting to become pregnant. Women with class 3 obesity had significantly greater odds of mistimed (adjusted odd ratio [aOR], 1.67; 95% confidence interval [CI], 1.02-2.75) or unwanted (aOR, 1.96; 95% CI, 1.15-3.32) pregnancy compared with normal weight women. Women with class 2 or 3 obesity were more likely to not be using contraception (aOR, 1.53-1.62; 95% CI, 1.04-2.29). Although women with class 2 obesity were more likely to be using long-acting reversible contraceptive methods and sterilization over short-acting hormonal methods (aOR, 1.67; 95% CI, 1.08-2.57; aOR, 2.05; 95% CI,1.44-2.91), this association was not observed among women with class 3 obesity.
Women with class 3 obesity are at greater risk of unintended pregnancy and are less likely to be using contraception than normal weight women. Whether these findings are related to patient and/or provider barriers that are not as visible among women with class 1 and class 2 obesity warrants further investigation.
肥胖与妊娠意愿之间关联的研究结果相互矛盾,这可能是由于肥胖的定义是体重指数(BMI)达到或超过 30kg/m2。然而,BMI 达到 40kg/m2 或更高的肥胖女性在行为和临床方面可能与 BMI 较低的肥胖女性有所不同。本研究重新审视了这种关系,按肥胖程度分层;本研究还探讨了不同肥胖程度人群的避孕方法使用情况,因为这些方法可能会对意外或非意愿妊娠的发生率产生影响。
本研究结合了 2006 年至 2010 年和 2011 年至 2013 年美国国家家庭增长调查的数据。妊娠意愿(计划妊娠、时机不当妊娠、非意愿妊娠)和当前避孕方法(无避孕方法、屏障避孕法、避孕药/贴片/环/注射、长效可逆避孕法、绝育)按 BMI 分类进行比较:正常(18.5-24.9kg/m2)、超重(25.0-29.9kg/m2)、肥胖 1 级(30.0-34.9kg/m2)、肥胖 2 级(35.0-39.9kg/m2)和肥胖 3 级(≥40kg/m2,严重肥胖)。体重指数类别和妊娠意愿的独立关联以及避孕方法的独立关联通过加权多项逻辑回归进行了细化,控制了人口统计学、社会经济和生殖因素。
共有 9848 名未怀孕、有性行为且报告不想怀孕的非孕妇参与了研究。肥胖 3 级的女性与正常体重女性相比,时机不当(调整后的优势比[aOR],1.67;95%置信区间[CI],1.02-2.75)或非意愿(aOR,1.96;95%CI,1.15-3.32)妊娠的可能性显著更高。肥胖 2 级或 3 级的女性更有可能不使用避孕措施(aOR,1.53-1.62;95%CI,1.04-2.29)。虽然肥胖 2 级的女性更有可能使用长效可逆避孕方法和绝育术,而不是短期激素避孕方法(aOR,1.67;95%CI,1.08-2.57;aOR,2.05;95%CI,1.44-2.91),但这种关联在肥胖 3 级的女性中并未观察到。
肥胖 3 级的女性意外怀孕的风险更高,且比正常体重女性更不可能使用避孕措施。这些发现是否与 1 级和 2 级肥胖女性中不太明显的患者和/或提供者障碍有关,需要进一步研究。