Cidon Esther Una
Medical Oncology Service, Clinical University Hospital, C/ Ramon y Cajal s/n, 47005, Valladolid, Spain. Email:
World J Oncol. 2010 Apr;1(2):87-90. doi: 10.4021/wjon2010.04.196w. Epub 2010 Apr 30.
Gastric cancer is one of the most frequent causes of death secondary to cancer in the world. Surgery is the only potentially curative treatment but its clinical consequences are significant. The objective of this study is to evaluate the nutritional state of patients with a total gastrectomy secondary to gastric adenocarcinoma.
We designed a descriptive study with a transversal cut in our institution. We included 22 patients which had a minimum evolution time of six months after total gastrectomy secondary to gastric cancer surgery was performed. Neither of them had metastasis. The nutritional analysis included only biochemical data. Descriptive statistics were used for statistical analysis.
Eight females and 14 males were included in the study. Median age was 57 years (34 - 69 years). The 74% of the patients were underweight and none of them was overweight. The average body mass index (BMI) was 16.88 kg/m. Eleven patients suffered from mild anemia (10.5 - 12 g/dl) and 5 from moderate anemia (9 - 10.5 g/dl). Only two patients presented severe anemia (less than 9 g/dl). The 58% presented hypoproteinaemia and hypoalbuminaemia. The main post-surgery complication was nausea (46%). Seventy-eight percent of the patients had loss of appetite. Twenty-one patients were able to walk without help and leave their homes.
The incidence of anemia in these patients was very high. In most of the patients, albumin and proteins levels were affected too. So malnutrition was a relevant consequence of a total gastrectomy.
胃癌是全球癌症相关死亡的最常见原因之一。手术是唯一可能治愈的治疗方法,但其临床后果较为严重。本研究的目的是评估胃腺癌全胃切除患者的营养状况。
我们在本机构设计了一项横断面描述性研究。纳入22例患者,这些患者在因胃癌手术行全胃切除术后至少有6个月的随访时间。他们均无转移。营养分析仅包括生化数据。采用描述性统计进行统计分析。
本研究纳入8名女性和14名男性。中位年龄为57岁(34 - 69岁)。74%的患者体重过轻,无超重患者。平均体重指数(BMI)为16.88kg/m。11例患者患有轻度贫血(10.5 - 12g/dl),5例患有中度贫血(9 - 10.5g/dl)。仅2例患者出现重度贫血(低于9g/dl)。58%的患者出现低蛋白血症和低白蛋白血症。术后主要并发症为恶心(46%)。78%的患者食欲不振。21例患者能够独立行走并离家外出。
这些患者贫血发生率非常高。大多数患者的白蛋白和蛋白质水平也受到影响。因此,营养不良是全胃切除术后的一个重要后果。