FA 和 T2* 参数联合在帕金森病治疗评估中的新诊断方法的作用。
Role of the combination of FA and T2* parameters as a new diagnostic method in therapeutic evaluation of parkinson's disease.
机构信息
Department of Magnetic Resonance Imaging, Qinhuangdao Municipal No. 1 Hospital, Qinhuangdao, P.R. China.
Applied Chemical Key Lab of Hebei Province, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
出版信息
J Magn Reson Imaging. 2018 Jul;48(1):84-93. doi: 10.1002/jmri.25900. Epub 2017 Nov 17.
BACKGROUND
Simple diffusion delivery (SDD) has attained good effects with only tiny amounts of drugs. Fractional anisotropy (FA) and relaxation time T2* that indicate the integrity of fiber tracts and iron concentration within brain tissue were used to evaluate the therapeutic effect of SDD.
PURPOSE
To evaluate therapeutic effect of SDD in the Parkinson's disease (PD) rat model with FA and T2* parameters.
STUDY TYPE
Prospective case-control animal study.
POPULATION
Thirty-two male Sprague Dawley rats (eight normal, eight PD, eight SDD, and eight subcutaneous injection rats).
FIELD STRENGTH/SEQUENCE: Single-shot spin echo echo-planar imaging and fast low-angle shot T WI sequences at 3.0T.
ASSESSMENT
Parameters of FA and T2* on the treated side of the substantia nigra were measured to evaluate the therapeutic effect of SDD in a PD rat model.
STATISTICAL TESTS
The effects of time on FA and T2* values were analyzed by repeated measurement tests. A one-way analysis of variance was conducted, followed by individual comparisons of the mean FA and T2* values at different timepoints.
RESULTS
The FA values on the treated side of the substantia nigra in the SDD treatment group and subcutaneous injection treatment group were significantly higher at week 1 and lower at week 6 than that of the PD control group (SDD vs. PD, week 1, adjusted P = 0.012; subcutaneous vs. PD, week 1, adjusted P < 0.001; SDD vs. PD, week 6, adjusted P = 0.004; subcutaneous vs. PD, week 6, adjusted P = 0.024). The T2* parameter in the SDD treatment group and subcutaneous injection treatment group was significantly higher than that in the PD control group at week 6 (SDD vs. PD, adjusted P = 0.032; subcutaneous vs. PD, adjusted P < 0.001).
DATA CONCLUSION
The combination of FA and T2* parameters can potentially serve as a new effective evaluation method of the therapeutic effect of SDD.
LEVEL OF EVIDENCE
1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2017.
背景
单纯扩散给药（SDD）只需使用少量药物就能取得良好的效果。分数各向异性（FA）和弛豫时间 T2* 可用于评估纤维束的完整性和脑内铁浓度，从而对 SDD 的治疗效果进行评估。
目的
利用 FA 和 T2* 参数评估 SDD 在帕金森病（PD）大鼠模型中的治疗效果。
研究类型
前瞻性病例对照动物研究。
研究对象
32 只雄性 Sprague Dawley 大鼠（正常 8 只，PD 8 只，SDD 8 只，皮下注射 8 只）。
磁场强度/序列：3.0T 下单次激发自旋回波回波平面成像和快速小角度激发 T2*WI 序列。
评估
测量黑质内处理侧的 FA 和 T2* 参数，以评估 PD 大鼠模型中 SDD 的治疗效果。
统计学分析
采用重复测量检验分析时间对 FA 和 T2* 值的影响。采用单因素方差分析，然后对不同时间点的平均 FA 和 T2* 值进行两两比较。
结果
SDD 治疗组和皮下注射治疗组黑质内处理侧的 FA 值在第 1 周显著升高，而在第 6 周显著降低，均明显高于 PD 对照组（SDD 与 PD 相比，第 1 周，调整后 P=0.012；皮下注射与 PD 相比，第 1 周，调整后 P＜0.001；SDD 与 PD 相比，第 6 周，调整后 P=0.004；皮下注射与 PD 相比，第 6 周，调整后 P=0.024）。SDD 治疗组和皮下注射治疗组的 T2* 参数在第 6 周时明显高于 PD 对照组（SDD 与 PD 相比，调整后 P=0.032；皮下注射与 PD 相比，调整后 P＜0.001）。
数据结论
FA 和 T2* 参数的联合应用可能成为 SDD 治疗效果的一种新的有效评估方法。
证据水平
1 技术功效：第 4 阶段 J. 磁共振成像 2017 年。
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