抗反转录病毒治疗时代的 HIV 感染成人肺部疾病。
Pulmonary disease in HIV-infected adults in the era of antiretroviral therapy.
机构信息
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Department of Medicine, Minneapolis VA Healthcare System.
出版信息
AIDS. 2018 Jan 28;32(3):277-292. doi: 10.1097/QAD.0000000000001712.
Abstract
: HIV in the antiretroviral therapy era is characterized by multimorbidity and the frequent occurrence of HIV-associated non-AIDS chronic health conditions. Respiratory symptoms and chronic pulmonary diseases, including chronic obstructive pulmonary disease, asthma, and cardiopulmonary dysfunction, are among the conditions that may present in persons living with HIV. Tobacco smoking, which is disproportionately high among persons living HIV, strongly contributes to the risk of pulmonary disease. Additionally, features associated with and at times unique to HIV, including persistent inflammation, immune cell activation, oxidative stress, and dysbiosis, may also contribute. This review summarizes the available literature regarding epidemiology of and risk factors for respiratory symptoms and chronic pulmonary disease in the current era.
摘要
在抗逆转录病毒治疗时代，艾滋病毒的特点是多病共存和经常发生与艾滋病毒相关的非艾滋病慢性健康状况。呼吸症状和慢性肺部疾病，包括慢性阻塞性肺疾病、哮喘和心肺功能障碍，是可能出现在艾滋病毒感染者中的病症之一。在艾滋病毒感染者中，吸烟的比例过高，这强烈增加了患肺病的风险。此外，与艾滋病毒相关且有时特有的特征，包括持续的炎症、免疫细胞激活、氧化应激和菌群失调，也可能起作用。这篇综述总结了当前时代有关呼吸道症状和慢性肺部疾病的流行病学和危险因素的现有文献。
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